Uniwersytet Medyczny w Łodzi, Klinika Psychiatrii Dorosłych.
Uniwersytet Medyczny w Łodzi, Zakład Chemii i Biochemii Klinicznej.
Psychiatr Pol. 2020 Jun 30;54(3):499-508. doi: 10.12740/PP/109130.
Depression is an important health problem around the world. There are several effective methods for its treatment, but it is estimated that one-third of patients with depression do not respond adequately to conventional antidepressants. There is, therefore, an urgent need to identify the biological mechanism of depression and the pharmacological action of antidepressants. The participation of broadly understood inflammatory factors in the etiology of depressive disorders no longer raises doubts. In recent years, a lot of attention has also been devoted to changes in the endoplasmic reticulum, suggesting that the so-called endoplasmic reticulum stress gives rise to many diseases. The endoplasmic reticulum stress is activated in response to the increasing amount of unfolded or improperly folded proteins in the ER. Research on the so-called endoplasmic reticulum stress inspire hope not only in the context of amore thorough understanding of the pathophysiology of diseases, but it can also be an inspiration to search for new, more effective drugs. This paper presents the connections between changes of the endoplasmic reticulum and inflammatory states and oxidative-reduction balance. Both the occurrence of inflammation and so-called oxidative stress have been confirmed in depressive disorders.
抑郁症是全球范围内一个重要的健康问题。有几种有效的治疗方法，但据估计，有三分之一的抑郁症患者对传统抗抑郁药反应不充分。因此，迫切需要确定抑郁症的生物学机制和抗抑郁药的药理作用。炎症因子在抑郁障碍发病机制中的广泛参与不再有疑问。近年来，人们也越来越关注内质网的变化，表明所谓的内质网应激会引发许多疾病。内质网应激是对内质网中未折叠或错误折叠蛋白质的增加的反应而被激活的。对所谓的内质网应激的研究不仅为更深入地了解疾病的病理生理学带来了希望，而且还为寻找新的、更有效的药物提供了灵感。本文介绍了内质网改变与炎症状态和氧化还原平衡之间的联系。在抑郁症中，炎症的发生和所谓的氧化应激都得到了证实。
