Huang Laixin, Shen Min, Liu Taiwei, Zhang Yan, Wang Yan
Department of Mechanics, School of Mechanical Engineering, Tianjin University, Tianjin 300350, China.
Department of Mechanics, School of Mechanical Engineering, Tianjin University, Tianjin 300350, China.
J Biomech. 2020 Nov 9;112:110055. doi: 10.1016/j.jbiomech.2020.110055. Epub 2020 Sep 28.
Assessing the biomechanical properties of the cornea in vivo is important for predicting the outcome of refractive surgery, and for controlling the risk of postoperative complications. In this study, we examined the impact of corneal mechanical properties (nonlinearity and anisotropy) on the inverse solution of corneal material parameters based on the non-contact tonometry ("air puff") test. Finite element models with different constitutive models (linear-elastic, isotropic hyperelastic, and fiber-dependent) were established to simulate the non-contact tonometry test. The results showed that the corneal nonlinear mechanical property and fiber distribution had significant effects on the corneal deflection profile. These findings may help in constructing an appropriate inverse solution strategy when using the inverse finite element method and in identifying individual differences in the corneal matrix shear modulus and fiber stiffness.
在体内评估角膜的生物力学特性对于预测屈光手术的结果以及控制术后并发症的风险非常重要。在本研究中，我们基于非接触眼压测量（“吹气”）试验，研究了角膜力学特性（非线性和各向异性）对角膜材料参数反解的影响。建立了具有不同本构模型（线弹性、各向同性超弹性和纤维依赖性）的有限元模型来模拟非接触眼压测量试验。结果表明，角膜非线性力学特性和纤维分布对角膜变形轮廓有显著影响。这些发现可能有助于在使用逆有限元方法时构建合适的反解策略，并识别角膜基质剪切模量和纤维刚度的个体差异。
