Jehan Sarwat, Iram Zunirah, Syed Sadiqa
Baqai Institute of Reproduction and Developmental Sciences (BIRDS), Karachi, Pakistan.
Department of Community Medicine, Princess Nourah bint Abdulrahman University, Riyadh, KSA.
J Pak Med Assoc. 2020 Sep;70(9):1538-1542. doi: 10.5455/JPMA.18623.
To determine the frequency of empty follicle syndrome in in-vitro fertilization-stimulated cycles and to evaluate the causes associated with this phenomenon.
The retrospective study was conducted at the Baqai Institute of Reproduction and Developmental Sciences, Karachi, and comprised data related to period from January 2012 to December 2016. Other than demographic information, laboratory investigations, ultrasound findings and treatment protocols were noted and evaluated. Data was statistically analysed using SPSS 21.
Of the 1120 cycles studied, empty follicle syndrome was found in 72 (6.4%). The possible leading causes included advanced age in 64 (88.8%) patients, longer duration of infertility in 56 (77.7%), higher baseline follicle stimulating hormone in 56 (77.7%), and lower oestradiol level before human chorionic gonadotrophin injection in 58 (80%). Empty follicles were significantly correlated with age of the patient, years of infertility, serum follicle stimulating hormone level and stimulation length (p<0.05).
Empty follicle syndrome is a rare occurrence. Screening of patients for risk factors before considering IVF cycles is mandatory. The patients should be counseled for possible EFS even in first cycle.
确定体外受精促排卵周期中空卵泡综合征的发生率，并评估与此现象相关的原因。
这项回顾性研究在卡拉奇的巴凯生殖与发育科学研究所进行，纳入了2012年1月至2016年12月期间的数据。除人口统计学信息外，还记录并评估了实验室检查、超声检查结果和治疗方案。使用SPSS 21对数据进行统计学分析。
在1120个研究周期中，发现72个（6.4%）为空卵泡综合征。可能的主要原因包括64例（88.8%）患者年龄较大，56例（77.7%）不孕时间较长，56例（77.7%）基础卵泡刺激素水平较高，58例（80%）人绒毛膜促性腺激素注射前雌二醇水平较低。空卵泡与患者年龄、不孕年限、血清卵泡刺激素水平和促排卵时间显著相关（p<0.05）。
空卵泡综合征较为罕见。在考虑进行体外受精周期之前，对患者进行危险因素筛查是必要的。即使在第一个周期，也应向患者咨询可能发生空卵泡综合征的情况。
