The Aga Khan University Hospital, Karachi, Pakistan.
Aga Khan University Hospital, Karachi.
J Pak Med Assoc. 2020 Sep;70(9):1667-1668.
Cerebellar Mutism Syndrome (CMS) is a well-described clinical entity that complicates surgeries for posterior fossa tumours; more so in children than adults. This review focuses on the current understanding of CMS, its incidence and risk factors. Incidence showed a variable range in retrospective studies due to variety of definitions. Risk factors can be classified as either modifiable including surgical technique, or non-modifiable which include tumour related factors. A positive correlation has been associated between tumour pathology, brain stem invasion and size of tumour at time of presentation with development of CMS.
小脑缄默症（CMS）是一种描述明确的临床病症，会使后颅窝肿瘤手术复杂化；儿童比成人更易发生。本综述重点介绍 CMS 的现有认知、发病率和危险因素。由于定义的多样性，回顾性研究的发病率显示出可变范围。危险因素可分为可改变的（包括手术技术）和不可改变的（包括肿瘤相关因素）。肿瘤病理学、脑干侵犯以及肿瘤在就诊时的大小与 CMS 的发生之间存在正相关。
