Mageed Mahmoud, Wegert Julius, Dyab Shahlaa, Gerlach Kerstin
Tierklinik Lüsche GmbH, Tierklinik Lüsche GmbH, Essenerstr. 39a, Bakum, 49456, Germany.
Departement for Horses, University of Leipzig, Leipzig, Germany.
Vet Radiol Ultrasound. 2021 Jan;62(1):126-132. doi: 10.1111/vru.12917. Epub 2020 Oct 11.
This prospective, cross-sectional, pilot study aimed to investigate the effects of furosemide as a diuretic on the image quality of bone scintigraphy performed using Tc-HDP and to investigate the impact of furosemide on the radiation dose rate. Thirty-one horses undergoing bone scintigraphy were included. The horses were divided into the control (n = 14) and furosemide group (n = 17), which received 1 mg/kg furosemide intravenously 1 h post Tc-HDP administration. The image quality was assessed subjectively and semi-quantitatively. The bone-to-soft tissue (B:S) ratio was calculated from the counts per pixel of regions of interest (ROI) positioned over the left radial diaphysis (bone ROI) and its caudal soft tissue area (soft tissue ROI). The radiation rate dose (μSv/h) of both groups was measured at 0, 3, 6, 12, 18, and 24 h post Tc-HDP administration at a distance of 0, 30, and 100 cm from the head, kidney, and pelvis. The results showed no significant differences in the B:S ratio or the radiation dose rate observed between the groups. However, the radiation dose rate decreased by 56% at 3 h post Tc-HDP administration and keeping a distance of 30 cm reduced the radiation dose rate by 65%. Administering furosemide does not improve the image quality or reduce the radiation dose rate. The authors recommend commencing with bone scintigraphy 3 h post Tc-HDP administration and keeping at least a distance of 30 cm from the horse to reduce the staff radiation dose.
这项前瞻性横断面试点研究旨在调查速尿作为利尿剂对使用锝-亚甲基二膦酸盐（Tc-HDP）进行骨闪烁显像图像质量的影响，并研究速尿对辐射剂量率的影响。纳入了31匹接受骨闪烁显像的马匹。这些马被分为对照组（n = 14）和速尿组（n = 17），速尿组在静脉注射Tc-HDP 1小时后静脉注射1mg/kg速尿。对图像质量进行主观和半定量评估。通过位于左桡骨干（骨感兴趣区）及其尾侧软组织区域（软组织感兴趣区）的感兴趣区（ROI）的每像素计数计算骨与软组织（B:S）比值。在静脉注射Tc-HDP后0、3、6、12、18和24小时，在距离头部、肾脏和骨盆0、30和100cm处测量两组的辐射率剂量（μSv/h）。结果显示，两组之间观察到的B:S比值或辐射剂量率没有显著差异。然而，静脉注射Tc-HDP后3小时辐射剂量率下降了56%，保持30cm的距离可使辐射剂量率降低65%。注射速尿并不能改善图像质量或降低辐射剂量率。作者建议在静脉注射Tc-HDP后3小时开始进行骨闪烁显像，并与马保持至少30cm的距离，以降低工作人员的辐射剂量。
