Wang Lizhi, Han Liyan, Wei Lai, Wang Zhiqiang
Department of Otolaryngology，Affiliated Zhongshan Hospital of Dalian University，Dalian，116001，China.
Department of Otolaryngology，the People's Hospital of Xinzhou.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Sep;34(9):781-784. doi: 10.13201/j.issn.2096-7993.2020.09.004.
To analyze the correlation of the degree of affective disorder and brain function changes by comparing the differences of resting-state functional Magnetic Resonance Imaging（rs-fMRI） between healthy volunteers without tinnitus and patients with tinnitus. A analysis of 19 patients with tinnitus and 15 healthy volunteers without tinnitus. The patients were divided into mild group and severe group according to tinnitus handicap inventory（THI）. Rs-fMRI was collected and the regional homogeneity（ReHo） analysis, amplitude of low-frequency fluctuation（ALFF） analysis, and fractional amplitude of low frequency fluctuation（fALFF） analysis of rs-fMRI were performed by DPABI software. Two-sample -test of the ReHo value, ALFF value and fALFF value between the mild group and the control group, the severe group and the control group, were performed respectively. The fALFF value of the left occipital gyrus in the mild group was higher than that in the control group, the difference was statistically significant（<0.05）, but there is no statistically significant difference of ALFF value and ReHo value between two groups. The ALFF value of the middle temporal gyrus（left）, superior frontal gyrus（right）, inferior frontal gyrus pars triangularis（left） and caudate nucleus（left） in the severe group were higher than those of the control group. But there was no significant difference in the fALFF value and the ReHo value. Different severity of affective disorder in patients with tinnitus have different areas of brain function abnormalities. Mild group was detected by fALFF analysis and the active brain area was the left middle occipital region. Severe group was detected by ALFF analysis. The active brain regions were left middle temporal gyrus, right superior frontal gyrus, left inferior frontal gyrus pars triangularis, and left caudate nucleus.
通过比较无耳鸣健康志愿者与耳鸣患者静息态功能磁共振成像（rs-fMRI）的差异，分析情感障碍程度与脑功能变化的相关性。对19例耳鸣患者和15例无耳鸣健康志愿者进行分析。根据耳鸣 handicap 量表（THI）将患者分为轻度组和重度组。采集 rs-fMRI 数据，并使用 DPABI 软件对 rs-fMRI 进行局部一致性（ReHo）分析、低频振幅（ALFF）分析和低频振幅分数（fALFF）分析。分别对轻度组与对照组、重度组与对照组的 ReHo 值、ALFF 值和 fALFF 值进行两样本 t 检验。轻度组左侧枕叶的 fALFF 值高于对照组，差异有统计学意义（<0.05），但两组间 ALFF 值和 ReHo 值无统计学差异。重度组左侧颞中回、右侧额上回、左侧额下回三角部和左侧尾状核的 ALFF 值高于对照组。但 fALFF 值和 ReHo 值无显著差异。耳鸣患者不同严重程度的情感障碍有不同的脑功能异常区域。轻度组通过 fALFF 分析检测到，活跃脑区为左侧枕中区域。重度组通过 ALFF 分析检测到。活跃脑区为左侧颞中回、右侧额上回、左侧额下回三角部和左侧尾状核。
