Department of Epidemiology, College of Public Health, University of Kentucky, 111 Washington Avenue Room 212C, Lexington, KY 40536, USA.
Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Imaging Research Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 5033, Cincinnati, OH 45229, USA.
Neurol Clin. 2020 Nov;38(4):913-936. doi: 10.1016/j.ncl.2020.07.008. Epub 2020 Sep 12.
A review of published articles examining the effects of manganese exposure to workers and community residents shows adverse neurologic outcomes. Innovative biomarkers, including those from neuroimaging, were incorporated into many of these studies to assess both manganese exposure and neurologic outcomes. A variety of health effects were evaluated, including cognitive and motor impairments. Studies of community participants residing near manganese point sources show variability in outcomes, reflecting the complexities of exposure measurement, individual absorption, and assessment of neurologic effects. The aging population provides insight into the impacts of chronic exposure in younger populations.
对研究锰暴露对工人和社区居民影响的已发表文章的回顾表明，存在不良神经学结果。许多研究都纳入了创新的生物标志物，包括神经影像学的生物标志物，以评估锰暴露和神经学结果。评估了各种健康影响，包括认知和运动障碍。对居住在锰排放源附近的社区参与者的研究表明，结果存在差异，这反映了暴露测量、个体吸收和神经学影响评估的复杂性。人口老龄化为了解年轻人群中的慢性暴露的影响提供了线索。
