益生菌、益生元、合生元和副益生菌作为肠道黏膜炎的一种治疗选择
Probiotics, Prebiotics, Synbiotics, and Paraprobiotics as a Therapeutic Alternative for Intestinal Mucositis.
作者信息
Batista Viviane Lima, da Silva Tales Fernando, de Jesus Luís Cláudio Lima, Coelho-Rocha Nina Dias, Barroso Fernanda Alvarenga Lima, Tavares Laisa Macedo, Azevedo Vasco, Mancha-Agresti Pamela, Drumond Mariana Martins
机构信息
Laboratório de Genética Celular e Molecular (LGCM), Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Faculdade de Minas, FAMINAS-BH, Belo Horizonte, Brazil.
出版信息
Front Microbiol. 2020 Sep 17;11:544490. doi: 10.3389/fmicb.2020.544490. eCollection 2020.
Intestinal mucositis, a cytotoxic side effect of the antineoplastic drug 5-fluorouracil (5-FU), is characterized by ulceration, inflammation, diarrhea, and intense abdominal pain, making it an important issue for clinical medicine. Given the seriousness of the problem, therapeutic alternatives have been sought as a means to ameliorate, prevent, and treat this condition. Among the alternatives available to address this side effect of treatment with 5-FU, the most promising has been the use of probiotics, prebiotics, synbiotics, and paraprobiotics. This review addresses the administration of these "biotics" as a therapeutic alternative for intestinal mucositis caused by 5-FU. It describes the effects and benefits related to their use as well as their potential for patient care.
肠道黏膜炎是抗肿瘤药物5-氟尿嘧啶（5-FU）的一种细胞毒性副作用，其特征为溃疡、炎症、腹泻和剧烈腹痛，这使其成为临床医学中的一个重要问题。鉴于该问题的严重性，人们一直在寻找治疗方法，以改善、预防和治疗这种病症。在解决5-FU治疗副作用的可用方法中，最有前景的是使用益生菌、益生元、合生元和类益生菌。本综述探讨了将这些“生物制剂”作为5-FU引起的肠道黏膜炎的治疗选择。它描述了与使用它们相关的效果和益处以及它们在患者护理方面的潜力。
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