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肝癌发生中的启动与促进

Initiation and promotion in hepatocarcinogenesis.

作者信息

Schulte-Hermann R

出版信息

Arch Toxicol. 1987;60(1-3):179-81. doi: 10.1007/BF00296976.

DOI:10.1007/BF00296976
PMID:3304207
Abstract

Initiation and promotion have been recognized as essential parts of the multi-stage concept of chemical carcinogenesis. In the liver, initiation by genotoxic carcinogens results in appearance of foci of phenotypically altered hepatocytes. Accelerated growth and phenotypic changes of these foci during tumor promotion by phenobarbital are described, and possible mechanisms of initiation and promotion considered.

摘要

启动和促进已被公认为化学致癌多阶段概念的重要组成部分。在肝脏中，遗传毒性致癌物引发的启动作用会导致表型改变的肝细胞灶出现。本文描述了苯巴比妥在肿瘤促进过程中这些病灶的加速生长和表型变化，并探讨了启动和促进的可能机制。

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Initiation and promotion in hepatocarcinogenesis.肝癌发生中的启动与促进
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2
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本文引用的文献

1
Response of liver foci in rats to hepatic tumor promoters.
Toxicol Pathol. 1982 Feb;10(2):63-68. doi: 10.1177/019262338201000209.
2
Biological markers of preneoplastic foci and neoplastic nodules in rodent liver.啮齿动物肝脏中癌前病灶和肿瘤结节的生物标志物。
Toxicol Pathol. 1982 Feb;10(2):19-34. doi: 10.1177/019262338201000206.
3
DRUG-INDUCED CHANGES IN THE LIVER ENDOPLASMIC RETICULUM: ASSOCIATION WITH DRUG-METABOLIZING ENZYMES.药物诱导的肝脏内质网变化：与药物代谢酶的关联
Minimal role of enhanced cell proliferation in skin tumor promotion by mirex: a nonphorbol ester-type promoter.
灭蚁灵作为一种非佛波酯型促癌剂，其增强细胞增殖在皮肤肿瘤促进过程中作用极小。
Environ Health Perspect. 1993 Dec;101 Suppl 5(Suppl 5):265-9. doi: 10.1289/ehp.93101s5265.
4
Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital.苯巴比妥暴露后小鼠肝前肿瘤性和肿瘤性病变中DNA合成的选择性诱导。
Environ Health Perspect. 1993 Dec;101 Suppl 5(Suppl 5):235-9. doi: 10.1289/ehp.93101s5235.
Science. 1963 Dec 27;142(3600):1657-8. doi: 10.1126/science.142.3600.1657.
4
Immunocytochemical demonstration of a phenobarbital-inducible cytochrome P450 in putative preneoplastic foci of rat liver.
Carcinogenesis. 1984 Feb;5(2):149-53. doi: 10.1093/carcin/5.2.149.
5
Hepatocellular glycogenosis and related pattern of enzymatic changes during hepatocarcinogenesis.肝细胞糖原贮积症及肝癌发生过程中相关的酶变化模式
Adv Enzyme Regul. 1984;22:97-121. doi: 10.1016/0065-2571(84)90010-4.
6
The sequential analysis of cancer development.癌症发展的序贯分析。
Adv Cancer Res. 1980;31:125-226. doi: 10.1016/s0065-230x(08)60658-2.
7
The stages of initiation and promotion in hepatocarcinogenesis.肝癌发生过程中的起始和促进阶段。
Biochim Biophys Acta. 1980 May 6;605(2):191-215. doi: 10.1016/0304-419x(80)90004-9.
8
Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters.撤除肿瘤启动子后大鼠肝脏中正常细胞和假定的肿瘤前体细胞的程序性死亡（凋亡）
Carcinogenesis. 1984 Apr;5(4):453-8. doi: 10.1093/carcin/5.4.453.
9
Inhibitory effect of nafenopin upon the development of diethylnitrosamine-induced enzyme-altered foci within the rat liver.萘酚平对二乙基亚硝胺诱导的大鼠肝脏酶改变灶形成的抑制作用。
Carcinogenesis. 1984 Jan;5(1):41-6. doi: 10.1093/carcin/5.1.41.
10
Histochemical and ultrastructural demonstration of gamma-glutamyl transpeptidase activity.γ-谷氨酰转肽酶活性的组织化学和超微结构显示
J Histochem Cytochem. 1969 Aug;17(8):517-26. doi: 10.1177/17.8.517.