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Immunocytochemical demonstration of a phenobarbital-inducible cytochrome P450 in putative preneoplastic foci of rat liver.

作者信息

Schulte-Hermann R, Roome N, Timmermann-Trosiener I, Schuppler J

出版信息

Carcinogenesis. 1984 Feb;5(2):149-53. doi: 10.1093/carcin/5.2.149.

DOI:10.1093/carcin/5.2.149
PMID:6697432
Abstract

Putative preneoplastic foci of rat liver, so far believed to be deficient in monooxygenases, are shown to contain a cytochrome P450 isoenzyme inducible by phenobarbital. The isoenzyme is also present and appears catalytically active in liver tumors obtained after promotion with phenobarbital and alpha-hexachlorocyclohexane.

摘要

相似文献

1
Immunocytochemical demonstration of a phenobarbital-inducible cytochrome P450 in putative preneoplastic foci of rat liver.
Carcinogenesis. 1984 Feb;5(2):149-53. doi: 10.1093/carcin/5.2.149.
2
Morphological alterations and DNase deficiency in phenobarbital promotion of N-nitrosomorpholine initiated rat hepatocarcinogenesis.
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Aberrant expression of adaptation to phenobarbital may cause selective growth of foci of altered cells in rat liver.对苯巴比妥适应性的异常表达可能导致大鼠肝脏中细胞改变灶的选择性生长。
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Phenobarbital induction of cytochrome P-450 in normal and preneoplastic rat liver: comparison of enzyme and mRNA expression as detected by immunohistochemistry and in situ hybridization.苯巴比妥对正常及癌前大鼠肝脏细胞色素P-450的诱导作用：免疫组织化学和原位杂交检测酶及mRNA表达的比较
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Promotion of spontaneous preneoplastic cells in rat liver as a possible explanation of tumor production by nonmutagenic compounds.大鼠肝脏中自发的癌前细胞的促进作用，作为非诱变化合物产生肿瘤的一种可能解释。
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Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin.用肿瘤启动剂苯巴比妥、六氯环己烷、类固醇化合物和萘酚平处理大鼠肝脏后，假定的肿瘤前体细胞增殖增强。
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Dose-response studies on the effects of alpha-, beta-, and gamma-hexachlorocyclohexane on putative preneoplastic foci, monooxygenases, and growth in rat liver.α-、β-和γ-六氯环己烷对大鼠肝脏中假定的癌前病灶、单加氧酶及生长影响的剂量反应研究。
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Enhancement of NNM-induced carcinogenesis in the rat liver by phenobarbital: a combined morphological and enzyme histochemical approach.苯巴比妥增强大鼠肝脏中NNM诱导的致癌作用：形态学与酶组织化学联合研究方法
Carcinogenesis. 1983;4(4):473-9. doi: 10.1093/carcin/4.4.473.

引用本文的文献

1
Tumor promotion in the liver.肝脏中的肿瘤促进作用。
Arch Toxicol. 1985 Aug;57(3):147-58. doi: 10.1007/BF00290879.
2
Initiation and promotion in hepatocarcinogenesis.肝癌发生中的启动与促进
Arch Toxicol. 1987;60(1-3):179-81. doi: 10.1007/BF00296976.
3
Expression and inducibility of drug-metabolizing enzymes in preneoplastic and neoplastic lesions of rat liver during nitrosamine-induced hepatocarcinogenesis.亚硝胺诱导大鼠肝癌发生过程中，大鼠肝脏癌前病变和肿瘤病变中药物代谢酶的表达及诱导性。
Arch Toxicol. 1987;60(1-3):198-203. doi: 10.1007/BF00296980.
4
Enzymes of glutathione metabolism as biochemical markers during hepatocarcinogenesis.谷胱甘肽代谢酶作为肝癌发生过程中的生化标志物。
Cancer Metastasis Rev. 1987;6(2):155-78. doi: 10.1007/BF00052847.
5
Effects of tobacco-specific nitrosamines and snuff extract on cell proliferation and activities of ornithine decarboxylase and aryl hydrocarbon hydroxylase in mouse tongue primary epithelial cell cultures.烟草特异性亚硝胺和鼻烟提取物对小鼠舌原代上皮细胞培养物中细胞增殖及鸟氨酸脱羧酶和芳烃羟化酶活性的影响。
J Cancer Res Clin Oncol. 1989;115(6):558-63. doi: 10.1007/BF00391358.
6
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital.2-乙酰氨基芴和苯巴比妥对肝癌发生促进作用的易感性的品系差异：2-乙酰氨基芴和苯巴比妥诱导细胞色素P-450同工酶的免疫组织化学分析
Jpn J Cancer Res. 1989 Nov;80(11):1041-6. doi: 10.1111/j.1349-7006.1989.tb02256.x.