Zhao Weisong, Wang Gangyang, Zhou Chenghao, Zhao Qinghua
Department of Orthopaedics, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200080, China.
First Clinical College, Xinxiang Medical University Xinxiang 453000, Henan, China.
Am J Transl Res. 2020 Sep 15;12(9):5882-5907. eCollection 2020.
Osteoporosis is a common metabolic bone disease characterized by low bone mineral density (BMD) and microarchitectural deterioration of bone tissue, which leads to decreased bone strength and increased fracture risk. Osteoporosis mainly results from a disruption of the balance between bone formation mediated by osteoblasts and bone resorption mediated by osteoclasts. At present, the molecular mechanisms underlying osteoporosis are still not fully understood. Long noncoding RNAs (lncRNAs) are RNA molecules that exceed 200 nucleotides (nt) in length and have limited or no protein-coding capacity. Over the past decade, numerous lncRNAs have been demonstrated to participate in multiple biological processes and to play essential roles in the pathogenesis of various diseases. In this review, we summarize recent progress in research on lncRNAs in osteoporosis and mainly focus on their regulatory roles in osteogenesis and osteoclastogenesis. Moreover, we briefly discuss the potential clinical applications of lncRNAs in osteoporosis.
骨质疏松症是一种常见的代谢性骨病，其特征为骨矿物质密度（BMD）降低和骨组织微结构破坏，进而导致骨强度下降和骨折风险增加。骨质疏松症主要是由成骨细胞介导的骨形成与破骨细胞介导的骨吸收之间的平衡失调所致。目前，骨质疏松症的分子机制仍未完全明确。长链非编码RNA（lncRNAs）是长度超过200个核苷酸（nt）且蛋白质编码能力有限或无蛋白质编码能力的RNA分子。在过去十年中，大量lncRNAs已被证明参与多种生物学过程，并在各种疾病的发病机制中发挥重要作用。在本综述中，我们总结了lncRNAs在骨质疏松症研究中的最新进展，主要关注它们在成骨和破骨细胞生成中的调节作用。此外，我们简要讨论了lncRNAs在骨质疏松症中的潜在临床应用。
