He Yinxi, Chen Yanxia
Department of Orthopaedic Trauma, The Third Hospital of Shijiazhuang, Shijiazhuang, 050000, Hebei, People's Republic of China.
Department of Endocrinology, The Second Hospital of Hebei Medical University, 215 Hepingxi Road, Shijiazhuang, 050000, Hebei, People's Republic of China.
J Bone Miner Metab. 2021 May;39(3):341-352. doi: 10.1007/s00774-021-01205-6. Epub 2021 Feb 10.
Osteoporosis is a common bone disease characterized by low bone mass and deterioration of bone microstructure, which predisposes to higher risks of bone fragility and bone fracture. Long non-coding RNAs (lncRNAs) are a class of RNAs with a length of > 200 nucleotides without protein-coding function, which control the expression of genes and affect multiple biological processes. Accumulating evidence suggests that lncRNAs are widely involved in the molecular mechanisms of osteoporosis. This review aims to summarize the function and underlying mechanism of lncRNAs involved in the development of osteoporosis, and how it contributes to osteoblast and osteoclast function. This knowledge will shed new light on the modulation and potential treatment of osteoporosis.
骨质疏松症是一种常见的骨骼疾病，其特征是骨量低和骨微结构退化，这会增加骨骼脆性和骨折的风险。长链非编码RNA（lncRNA）是一类长度大于200个核苷酸且无蛋白质编码功能的RNA，它们控制基因表达并影响多个生物学过程。越来越多的证据表明，lncRNA广泛参与骨质疏松症的分子机制。本综述旨在总结lncRNA在骨质疏松症发生发展中的功能及潜在机制，以及它们如何影响成骨细胞和破骨细胞的功能。这些知识将为骨质疏松症的调控和潜在治疗提供新的思路。
