Ficken M D, Edwards J F, Lay J C, Tveter D E
Avian Dis. 1987 Apr-Jun;31(2):241-8.
Tracheal mucus transport rate (TMTR) and quantitative clearance of aerosolized Escherichia coli from the trachea, lung, and air sac were measured in healthy unanesthetized turkeys and in turkeys exposed by aerosol to a La Sota vaccine strain of Newcastle disease virus (NDV). The TMTR of uninfected turkeys was 42.4 +/- 14.7 cm/min. The TMTR of NDV-infected turkeys was depressed on days 3 through 7 postexposure (PE); depression was significant (P less than or equal to 0.05) on day 7 PE. Tracheal E. coli clearance in NDV-infected turkeys was reduced on days 4 through 9 PE, significantly so on day 5 PE (P less than or equal to 0.01). Depression of TMTR and tracheal E. coli clearance were associated histologically with replacement of normal pseudostratified columnar epithelium by 3 to 8 layers of immature nonciliated cells. E. coli clearance by the lung and air sac of NDV-infected turkeys was depressed on days 5 through 9 PE.
在健康未麻醉的火鸡以及通过气溶胶暴露于新城疫病毒（NDV）La Sota疫苗株的火鸡中，测量了气管黏液运输速率（TMTR）以及气管、肺和气囊中雾化大肠杆菌的定量清除情况。未感染火鸡的TMTR为42.4±14.7厘米/分钟。在暴露后（PE）第3至7天，感染NDV的火鸡的TMTR降低；在PE第7天，降低显著（P≤0.05）。在PE第4至9天，感染NDV的火鸡气管中大肠杆菌的清除率降低，在PE第5天显著降低（P≤0.01）。TMTR降低和气管中大肠杆菌清除率降低在组织学上与正常假复层柱状上皮被3至8层未成熟无纤毛细胞取代有关。在PE第5至9天，感染NDV的火鸡的肺和气囊对大肠杆菌的清除率降低。
