Ambe Solomon, Nizamutdinov Damir, Huang Jason H, Fonkem Ekokobe
Neurology, Tulane University School of Medicine, New Orleans, USA.
Neurosurgery, Baylor Scott & White Health, Temple, USA.
Cureus. 2020 Sep 3;12(9):e10235. doi: 10.7759/cureus.10235.
Primary central nervous system (CNS) tumors constitute a group of rare and heterogeneous tumors. A rising incidence rate in the United States has been linked to modern changes in early diagnosis and reporting. This study aims to examine temporal incidence trends, geographic variation, and the average annual age-adjusted rates among Hispanic populations in Texas from 1995 to 2013.
SEER*STAT (Surveillance Research Program, National Cancer Institute (seer.cancer.gov/seerstat) version 8.3.2) and Joinpoint Regression 4.4.0.0 (Statistical Methodology and Applications Branch, Surveillance Research Program, National Cancer Institute) software were used to analyze incidence of primary brain and CNS tumors among Texas residents. Data were obtained from the Texas Cancer Registry of the Texas Department of State Health Services.
From the 30,122 cases of primary CNS tumors diagnosed throughout the state of Texas from 2008 to 2012, the overall average annual age-adjusted incidence rate for Hispanics and non-Hispanics combined was 25.35 per 100,000 persons. Among Hispanics, West Texas had the highest incidence trends and the highest average age-adjusted incidence rate of 27.17, followed by North Texas at 26.01 and the Panhandle at 23.63. East Texas had the lowest incidence rate of 16.23. The incidence trend among Hispanics has decreased consistently at a rate of 0.83 % from 1995 to 2013.
The incidence of tumors was more pronounced in the Hispanic population in northern Texas compared with southern Texas. The presence of oil and gas production industries with farming and construction could play a role in the observed incidence of disease. Further studies with a focus on occupational health among Hispanics in Texas will be needed to elucidate the cause of such distribution.
原发性中枢神经系统（CNS）肿瘤是一组罕见且异质性的肿瘤。美国发病率的上升与早期诊断和报告方面的现代变化有关。本研究旨在调查1995年至2013年德克萨斯州西班牙裔人群中原发性中枢神经系统肿瘤的时间发病率趋势、地理差异以及年龄调整后的年均发病率。
使用SEER*STAT（监测研究项目，美国国家癌症研究所（seer.cancer.gov/seerstat）8.3.2版本）和Joinpoint回归4.4.0.0（统计方法与应用分支，监测研究项目，美国国家癌症研究所）软件分析德克萨斯州居民原发性脑和中枢神经系统肿瘤的发病率。数据来自德克萨斯州卫生服务部的德克萨斯癌症登记处。
在2008年至2012年德克萨斯州确诊的30122例原发性中枢神经系统肿瘤病例中，西班牙裔和非西班牙裔人群合并后的总体年龄调整年均发病率为每10万人25.35例。在西班牙裔人群中，西德克萨斯州的发病率趋势最高，年龄调整后的平均发病率最高，为27.17，其次是北德克萨斯州，为26.01，狭长地带为23.63。东德克萨斯州的发病率最低，为16.23。1995年至2013年，西班牙裔人群的发病率趋势以每年0.83%的速度持续下降。
与德克萨斯州南部相比，德克萨斯州北部西班牙裔人群中的肿瘤发病率更为明显。石油和天然气生产行业与农业和建筑业并存可能是观察到的疾病发病率的一个影响因素。需要进一步开展聚焦于德克萨斯州西班牙裔职业健康的研究，以阐明这种分布的原因。
