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雾化甲状腺激素可预防辐射诱导的肺纤维化。

Aerosolized Thyroid Hormone Prevents Radiation Induced Lung Fibrosis.

作者信息

Li Long, Nie Xiaoqi, Yi Minxiao, Qin Wan, Li Fang, Wu Bili, Yuan Xianglin

机构信息

Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

出版信息

Front Oncol. 2020 Sep 15;10:528686. doi: 10.3389/fonc.2020.528686. eCollection 2020.

DOI:10.3389/fonc.2020.528686
PMID:33042829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7523090/
Abstract

Radiation induced lung fibrosis (RILF) is a common late complication after radiotherapy without effective treatment. Thyroid hormone (TH) is known to reverse bleomycin-induced pulmonary fibrosis in recent study. We therefore sought to examine TH effect in RILF. Aerosolized TH delivery prevented pulmonary fibrosis according to either micro-computed tomography scans or histological evaluations, without significant changes in serum THs in a murine model of RILF by attenuating TGF-β1 and phosphorylated Smad2/3 expressions and reducing the accumulation of M2-like macrophages. Furthermore, hypothyroidism was significantly correlated with RILF in a retrospectively analyzed data from nasopharyngeal carcinoma patients treated by intensity-modulated radiation therapy with a median follow-up time of 25.5 months. Together, aerosolized TH may prevent RILF by inhibiting the TGF-β1/SMADs signaling pathway.

摘要

放射性肺纤维化（RILF）是放疗后常见的晚期并发症，目前尚无有效治疗方法。近期研究表明，甲状腺激素（TH）可逆转博来霉素诱导的肺纤维化。因此，我们试图研究TH在RILF中的作用。在RILF小鼠模型中，通过雾化吸入TH给药，根据微型计算机断层扫描或组织学评估，可预防肺纤维化，且血清THs无显著变化，这是通过减弱TGF-β1和磷酸化Smad2/3表达以及减少M2样巨噬细胞的积累实现的。此外，在一项对接受调强放疗的鼻咽癌患者进行回顾性分析的数据中，甲状腺功能减退与RILF显著相关，中位随访时间为25.5个月。总之，雾化吸入TH可能通过抑制TGF-β1/SMAD信号通路预防RILF。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5791/7523090/db9c6ad15fff/fonc-10-528686-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5791/7523090/bed8ed4b1141/fonc-10-528686-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5791/7523090/cec39b279d3a/fonc-10-528686-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5791/7523090/eccc381d7da4/fonc-10-528686-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5791/7523090/e969e7f0fd77/fonc-10-528686-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5791/7523090/9995d28882e4/fonc-10-528686-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5791/7523090/db9c6ad15fff/fonc-10-528686-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5791/7523090/bed8ed4b1141/fonc-10-528686-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5791/7523090/cec39b279d3a/fonc-10-528686-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5791/7523090/eccc381d7da4/fonc-10-528686-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5791/7523090/e969e7f0fd77/fonc-10-528686-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5791/7523090/9995d28882e4/fonc-10-528686-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5791/7523090/db9c6ad15fff/fonc-10-528686-g006.jpg

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