Wang Yuxin, Luo Jinmei, Huang Rong, Xiao Yi
Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
BMC Pulm Med. 2025 Mar 19;25(1):126. doi: 10.1186/s12890-025-03584-2.
Thyroid hormones play a crucial role in numerous physiological processes, including pulmonary function. However, the relationship between thyroid function and different patterns of pulmonary ventilation remains unclear.
This study employed a bidirectional two-sample Mendelian randomization (MR) approach combined with a cross-sectional study from the National Health and Nutrition Examination Survey (NHANES) to explore the relationship between thyroid function and pulmonary ventilation indicators. We used genomic data from the ThyroidOmics Consortium and the UK Biobank to derive instrumental variables for thyroid and pulmonary functions. Adults from the NHANES 2007-2012 were included to validate the MR findings through weighted generalized linear model (GLM) regression and restricted cubic spline (RCS) analysis.
Genetically predicted thyroid-stimulating hormone (TSH) was associated with pulmonary ventilatory function (forced expiratory volume in 1 s (FEV1): β = 0.0223, 95% confidence interval (CI) 0.0040-0.0406, p-value = 0.0170), particularly with a restrictive ventilatory pattern (forced vital capacity (FVC): β = 0.0237, 95% CI 0.0047-0.0427, p-value = 0.0143). This association was more robust in the low TSH subgroup. Additionally, the NHANES data revealed a nonlinear relationship between both FEV1% predicted and FVC% predicted and TSH, characterized by a positive relationship at lower TSH ranges and a negative relationship at higher TSH ranges.
Our findings highlight a significant association between TSH levels and a restrictive ventilatory pattern, underscoring the importance of thyroid health in the clinical evaluation of certain pulmonary diseases. These insights may guide more personalized interventions in respiratory medicine.
甲状腺激素在包括肺功能在内的众多生理过程中发挥着关键作用。然而，甲状腺功能与不同模式的肺通气之间的关系仍不清楚。
本研究采用双向两样本孟德尔随机化（MR）方法，并结合来自美国国家健康与营养检查调查（NHANES）的横断面研究，以探讨甲状腺功能与肺通气指标之间的关系。我们使用来自甲状腺组学联盟和英国生物银行的基因组数据来推导甲状腺和肺功能的工具变量。纳入2007 - 2012年NHANES的成年人，通过加权广义线性模型（GLM）回归和受限立方样条（RCS）分析来验证MR结果。
基因预测的促甲状腺激素（TSH）与肺通气功能相关（第1秒用力呼气量（FEV1）：β = 0.0223，95%置信区间（CI）0.0040 - 0.0406，p值 = 0.0170），特别是与限制性通气模式相关（用力肺活量（FVC）：β = 0.0237，95% CI 0.0047 - 0.0427，p值 = 0.0143）。这种关联在低TSH亚组中更强。此外，NHANES数据显示预测的FEV1%和预测的FVC%与TSH之间存在非线性关系，其特征是在较低TSH范围内呈正相关，在较高TSH范围内呈负相关。
我们的研究结果突出了TSH水平与限制性通气模式之间的显著关联，强调了甲状腺健康在某些肺部疾病临床评估中的重要性。这些见解可能会为呼吸医学中的更个性化干预提供指导。
