Department of Ophthalmology, University of Health Sciences, Istanbul Training and Research Hospital, Istanbul, Turkey.
Department of Internal Medicine, University of Health Sciences, Istanbul Training and Research Hospital, Istanbul, Turkey.
Curr Eye Res. 2021 Jun;46(6):818-823. doi: 10.1080/02713683.2020.1836228. Epub 2020 Oct 22.
To investigate diabetic retinopathy (DR), plasma long pentraxin-3 (PTX-3) and taurine levels, and systemic factors in patients with type 2 diabetes mellitus (DM).
Patients with type 2 DM were categorized based on the presence of DR and maculopathy. Retinal findings (retinopathy, maculopathy, flame-shaped hemorrhage, intraretinal microvascular abnormalities, neovascularization of the optic disc, neovascularization elsewhere, and soft exudate); laboratory findings (fasting blood glucose, glycosylated hemoglobin [HbA1c], Taurine, PTX-3); systolic blood pressure (SBP) and diastolic blood pressure (DBP) were analyzed.
In this study, 39 patients with a mean age of 59.5 ± 8.1 years were included. The mean taurine level was significantly lower ( = .025) and HbA1c values were significantly higher ( = .0001) in patients with and without DR, respectively. In patients with varying severity of DR, a significant difference in the plasma taurine level was found ( = .0001). The mean PTX-3 level decreased with the severity of retinopathy; however, there was no significant difference in levels among the grading groups ( = .732). Taurine and PTX-3 levels were significantly lower in patients with maculopathy ( = .001 and = .022, respectively) and significantly higher in patients with grade 0 maculopathy than in those with grade 1, 2, or 3 maculopathy ( = .023, = .01, and = .01, respectively). Patients with flame-shaped hemorrhage had significantly lower PTX-3 levels ( = .009) and higher SBP and DBP levels ( = .003, = .023) than those without the hemorrhage.
No significant relation between PTX-3 level and severity of DR was found. HbA1c, taurine, and PTX-3 levels in patients with vision-threatening DR symptoms were significantly different from those without these symptoms. Management of systemic blood pressure and glycemic control is mandatory in the follow-up of DR, and increasing the plasma taurine levels can prevent vision loss.
探讨 2 型糖尿病（DM）患者糖尿病视网膜病变（DR）、血浆长 pentraxin-3（PTX-3）和牛磺酸水平及全身因素。
根据是否存在 DR 和黄斑病变，将 2 型 DM 患者进行分类。分析视网膜病变（视网膜病变、黄斑病变、火焰状出血、视网膜内微血管异常、视盘新生血管、其他部位新生血管和软性渗出物）、实验室检查（空腹血糖、糖化血红蛋白[HbA1c]、牛磺酸、PTX-3）、收缩压（SBP）和舒张压（DBP）。
本研究共纳入 39 例患者，平均年龄 59.5±8.1 岁。与无 DR 患者相比，DR 患者的牛磺酸水平显著降低（ =0.025），HbA1c 值显著升高（ =0.0001）。在不同严重程度的 DR 患者中，血浆牛磺酸水平存在显著差异（ =0.0001）。PTX-3 水平随视网膜病变严重程度降低，但各分级组之间水平无显著差异（ =0.732）。黄斑病变患者的牛磺酸和 PTX-3 水平显著降低（ =0.001 和 =0.022），0 级黄斑病变患者的牛磺酸和 PTX-3 水平显著高于 1 级、2 级和 3 级黄斑病变患者（ =0.023、 =0.01 和 =0.01）。有火焰状出血的患者 PTX-3 水平显著降低（ =0.009），SBP 和 DBP 水平显著升高（ =0.003、 =0.023）。
未发现 PTX-3 水平与 DR 严重程度之间存在显著关系。有威胁视力的 DR 症状的患者与无症状患者的 HbA1c、牛磺酸和 PTX-3 水平有显著差异。在 DR 的随访中，必须对全身血压和血糖控制进行管理，增加血浆牛磺酸水平可预防视力丧失。
