Bernard A, Passelecq B, Foidart J M, Mahieu P, Lauwerys R
Biomed Pharmacother. 1987;41(4):183-6.
Antibodies directed against laminin, a glycoprotein of basement membranes, have been sought for in the sera of 347 healthy subjects by a method relying on the agglutination of laminin-coated latex particles. Fifty-five subjects (15.9%) hae been found to be positive, 37 with a titre of 2, 14 with a titre of 4 and 4 with a titer of 8. Applied to 106 patients whose a renal biopsy had been examined by immunofluorescence, the test yielded positive results in 91% of patients with linear deposits as compared to 10.3 and 15.4% respectively in patients presenting with and without granular deposits along the glomerular basement membrane. The titers in anti-laminin antibodies observed in these patients ranged from 2 to 8. The discovery of circulating anti-laminin antibodies in serum from subjects without clinical or subclinical sign of renal impairment rises several questions regarding the pathogenicity of these auto-antibodies and their possible association with genetic or environmental factors.
采用基于层粘连蛋白包被乳胶颗粒凝集的方法，在347名健康受试者的血清中寻找针对基底膜糖蛋白层粘连蛋白的抗体。发现55名受试者（15.9%）呈阳性，其中37人滴度为2，14人滴度为4，4人滴度为8。将该检测应用于106例经免疫荧光检查过肾活检的患者，结果显示，与沿肾小球基底膜有颗粒状沉积物和无颗粒状沉积物的患者分别为10.3%和15.4%相比，线性沉积物患者中有91%呈阳性。这些患者中观察到的抗层粘连蛋白抗体滴度范围为2至8。在无肾脏损害临床或亚临床迹象的受试者血清中发现循环抗层粘连蛋白抗体，引发了关于这些自身抗体的致病性及其与遗传或环境因素可能关联的若干问题。
