Lancellotti Francesco, Solinas Luigi, Telesco Davide, Sagnotta Andrea, Belardi Augusto, Balsamo Giuseppina, Mancini Stefano
Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
Department of General Surgery and Surgical Oncology, San Filippo Neri Hospital, Rome, Italy.
Clin J Gastroenterol. 2021 Feb;14(1):115-122. doi: 10.1007/s12328-020-01255-9. Epub 2020 Oct 12.
Gastrointestinal neuroendocrine tumor (NET) associated with a metachronous intestinal adenocarcinoma is rare. We report the case of a 71-year-old man with an ileal NET. Patient has previously undergone a left colectomy for sigmoid cancer. We report a complete review both of the metachronous and synchronous NET. A comprehensive systematic literature search in PubMed, EMBASE, and MEDLINE identified a total of 35 relevant studies. This study includes an analysis of review articles, case reports, case series, retrospective studies and population-based studies. In the English literature to date, there are 21 case reports (19 synchronous cases and 2 metachronous cases), 3 case series and 3 review articles, and less than 10 retrospective studies or population-based studies. A total of 31 patients in 24 articles were included in the study: 28 patients with a synchronous gastrointestinal NET and colorectal adenocarcinoma and 3 patients with metachronous gastrointestinal NET and colorectal adenocarcinoma. The incidence of synchronous cancer (particularly for colorectal and gastric cancer) with a gastrointestinal NET ranges from 10 to 50%, while for the metachronous ones it is still unclear. This is the third metachronous case report and the first descriptive case of gastrointestinal NET diagnosed 2 years after a colorectal adenocarcinoma. An endoscopic follow-up program for gastrointestinal NET patients and/or for first-degree relatives of NET patients appears recommendable.
胃肠道神经内分泌肿瘤（NET）合并异时性肠腺癌较为罕见。我们报告一例71岁患有回肠NET的男性病例。该患者此前因乙状结肠癌接受了左半结肠切除术。我们报告了对异时性和同时性NET的全面回顾。在PubMed、EMBASE和MEDLINE中进行的全面系统文献检索共确定了35项相关研究。本研究包括对综述文章、病例报告、病例系列、回顾性研究和基于人群的研究的分析。在迄今为止的英文文献中，有21例病例报告（19例同时性病例和2例异时性病例）、3个病例系列和3篇综述文章，以及少于10项回顾性研究或基于人群的研究。24篇文章中共纳入31例患者：28例同时性胃肠道NET和结直肠癌患者，3例异时性胃肠道NET和结直肠癌患者。胃肠道NET合并同时性癌症（尤其是结直肠癌和胃癌）的发生率为10%至50%，而异时性癌症的发生率仍不清楚。这是第三例异时性病例报告，也是第一例在结直肠癌后2年诊断出胃肠道NET的描述性病例。对于胃肠道NET患者和/或NET患者的一级亲属，内镜随访计划似乎是可取的。
