神经内分泌肿瘤患者的异时性和同时性癌症。
Metachronous and Synchronous Cancers in Patients with Neuroendocrine Tumors.
机构信息
Oncology Unit, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Aprilia, Italy.
Oncology Unit, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Aprilia, Italy,
出版信息
Oncology. 2020;98(1):10-15. doi: 10.1159/000502384. Epub 2019 Sep 10.
INTRODUCTION
Neuroendocrine tumors (NETs) are a heterogeneous group of malignancies with various clinical presentations and growth rates. NET incidence has been estimated to 2.5-5 per 100,000 people per year, and NET prevalence is 35 per 100,000. They are frequently associated with synchronous or metachronous second primary malignancies (SPM).
METHODS
We retrospectively reviewed our institutional database on NET patients. We report on 30 patients with NETs and SPMs from a series of 262 patients with NETs: 10 patients with synchronous NETs (33.3%) and 20 with metachronous SPMs (66.6%).
RESULTS
The median patient age was 67 years. Of the 10 synchronous lesions, 50% were observed in the GI tract. The most common locations of these lesions were the colon (15%) and pancreas (25%). In 2 patients, there was an association of prostate neoplasia with a subsequent NET of the pancreas.
CONCLUSIONS
Only few studies have examined the association between NETs and SPMs. Our study showed that the risk of second cancer following NETs is increased. In this single-institution retrospective review, our incidence of additional malignancies in patients with NET was 11.4%.
简介
神经内分泌肿瘤（NETs）是一组具有不同临床表现和生长速度的异质性恶性肿瘤。NET 的发病率估计为每年每 10 万人中有 2.5-5 人，患病率为每 10 万人中有 35 人。它们常与同时性或异时性第二原发恶性肿瘤（SPM）相关。
方法
我们对我们的机构数据库中 NET 患者进行了回顾性研究。我们报告了来自 262 例 NET 患者系列中的 30 例 NET 和 SPM 患者：10 例为同时性 NET（33.3%）和 20 例为异时性 SPM（66.6%）。
结果
中位患者年龄为 67 岁。在 10 个同时性病变中，50%发生在胃肠道。这些病变最常见的部位是结肠（15%）和胰腺（25%）。在 2 例患者中，前列腺肿瘤与随后的胰腺 NET 有关。
结论
只有少数研究检查了 NET 和 SPM 之间的关联。我们的研究表明，NET 后发生第二癌的风险增加。在这项单机构回顾性研究中，我们的 NET 患者发生额外恶性肿瘤的发病率为 11.4%。
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