School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.
School of Functional Food and Wine, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.
Int Immunopharmacol. 2020 Dec;89(Pt A):107029. doi: 10.1016/j.intimp.2020.107029. Epub 2020 Oct 10.
Growing evidence shows that gut microbiota and neuroinflammatory responses play a critical role in the pathogenesis of depression. Our previous study demonstrated that schisandrin (SCH) could reduce proinflammatory factors of depressive mice. Therefore, our present study is to research the potential connection between gut microbial and anti-inflammatory effects of SCH on a depressive mouse model induced by lipopolysaccharide (LPS). We found that SCH pre-treatment could decrease the immobility time of forced swimming test (FST) and tail suspension test (TST). And the results of 16S rRNA demonstrated that SCH pre-administration attenuated the dysbiosis of gut microbiota of depressive mice, along with altered fecal short-chain fatty acids (SCFAs). Furthermore, SCH reduced the levels of proinflammatory factors of depressive mice and the expression of TLR4/NF-κB signaling pathway in the hippocampus. Overall, our study indicated that SCH might recover the gut microbial disorder of depressive mice through suppressing the expression of TLR4/NF-κB signaling pathway.
越来越多的证据表明，肠道微生物群和神经炎症反应在抑郁症的发病机制中起着关键作用。我们之前的研究表明，五味子醇甲（SCH）可以减少抑郁小鼠的促炎因子。因此，本研究旨在研究 LPS 诱导的抑郁小鼠模型中，SCH 的肠道微生物和抗炎作用之间的潜在联系。我们发现，SCH 预处理可以减少强迫游泳试验（FST）和悬尾试验（TST）中不动时间。16S rRNA 的结果表明，SCH 预处理可减轻抑郁小鼠肠道微生物群的失调，并改变粪便短链脂肪酸（SCFAs）。此外，SCH 降低了抑郁小鼠的促炎因子水平和 TLR4/NF-κB 信号通路在海马中的表达。总的来说，我们的研究表明，SCH 可能通过抑制 TLR4/NF-κB 信号通路的表达来恢复抑郁小鼠的肠道微生物失调。
