Ammann D, Oesch U, Bührer T, Simon W
Can J Physiol Pharmacol. 1987 May;65(5):879-84. doi: 10.1139/y87-141.
Requirements for a reliable use of liquid membrane microelectrodes are discussed in terms of stability, response time, and lifetime on the basis of membrane technological considerations. The selectivity of H+, Li+, Na+, K+, Mg2+, Ca2+, and Cl- microelectrodes is critically evaluated using the Nikolskii-Eisenman formalism. Recent progress in the design of new ionophores is presented. A novel neutral carrier-based Ca2+-selective microelectrode with a detection limit of about 5 X 10(-10) M Ca2+ at a background of 125 mM K+ has been realized. An neutral carrier-based microelectrode for H+ with extended pH range of the sample solution is now available. Promising developments in the field of Li+-, Mg2+-, and Cl--selective ionophores are discussed.
基于膜技术考量，从稳定性、响应时间和寿命方面讨论了可靠使用液膜微电极的要求。使用尼科尔斯基-艾森曼公式对H⁺、Li⁺、Na⁺、K⁺、Mg²⁺、Ca²⁺和Cl⁻微电极的选择性进行了严格评估。介绍了新型离子载体设计的最新进展。已实现一种新型基于中性载体的Ca²⁺选择性微电极，在125 mM K⁺背景下检测限约为5×10⁻¹⁰ M Ca²⁺。现在有一种基于中性载体的H⁺微电极，可用于样品溶液pH范围扩展的情况。讨论了Li⁺、Mg²⁺和Cl⁻选择性离子载体领域的有前景的发展。
