Nagabhushan M, Amonkar A J, Bhide S V
Cancer Lett. 1987 Aug;36(2):221-33. doi: 10.1016/0304-3835(87)90094-2.
Ginger extract and its constituents gingerol, shogaol and zingerone were tested in Salmonella typhimurium strains TA 100, TA 98, TA 1535 and TA 1538 in the presence and in absence of S9 mix. It was observed that ginger extract, gingerol and shogaol were mutagenic on metabolic activation in strains TA 100 and TA 1535, but zingerone was non-mutagenic in all the four strains with or without S9 mix. When mutagenicity of gingerol and shogaol was tested in presence of different concentrations of zingerone it was observed that zingerone suppressed mutagenic activity in both the compounds in a dose dependent manner.
在有和没有S9混合物存在的情况下，对姜提取物及其成分姜辣素、姜酚和姜酮在鼠伤寒沙门氏菌TA 100、TA 98、TA 1535和TA 1538菌株中进行了测试。观察到姜提取物、姜辣素和姜酚在TA 100和TA 1535菌株中经代谢活化后具有致突变性，但姜酮在有或没有S9混合物的所有四种菌株中均无致突变性。当在不同浓度的姜酮存在下测试姜辣素和姜酚的致突变性时，观察到姜酮以剂量依赖的方式抑制了这两种化合物的致突变活性。
