LIFE Research Group, University Jaume I, Castellon, Spain.
Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal.
Eur J Clin Invest. 2021 Apr;51(4):e13430. doi: 10.1111/eci.13430. Epub 2020 Nov 24.
The aim of this prospective cohort study was to examine whether the association between the cardiorespiratory fitness (CRF) at baseline and blood pressure (BP) at follow-up is mediated by adiposity in adolescents.
The sample comprised 734 adolescents (349 girls) aged 12-18 years from the LabMed Physical Activity Cohort Study. The variables of interest were measured in 2011 (baseline) and in 2013 (2-year follow-up). CRF was assessed by the 20-m shuttle run test. Body mass index, waist circumference, body fat percentage, pubertal status and resting BP were assessed according to standard procedures. Boot-strapped mediation procedures were performed, and indirect effects (IE) with confidence intervals (CI) not including zero were considered statistically significant.
After adjusting for potential confounders, body mass index acted as a mediator of the relationship between CRF and systolic BP (IE = -0. 023; CI = -0.039; -0.009), pulse pressure (IE = -0.023; CI = -0.034; -0.012) and rate product pressure (IE = -2.839; CI = -5.329; -0.340). Similar results were obtained for waist circumference as mediator for systolic BP (IE = -0.019; CI = -0.033; -0.005), pulse pressure (IE = -0.017; CI = -0.028; -0.007) and rate product pressure (IE = -3.793; CI = -6.097; -1.689). Likewise, body fat percentage mediated the association for: systolic BP (IE = -0.029; CI = -0.048; -0.010), pulse pressure (IE = -0.027; CI = -0.041; -0.013) and rate product pressure (IE = -4.280; CI = -7.488; -1.264).
Adiposity mediated the association between CRF and BP in adolescents. Therefore, both optimal CRF and adiposity levels are important to maintain normal BP ranges throughout adolescence.
本前瞻性队列研究旨在探讨青少年时期心肺适能（CRF）与随访时血压（BP）之间的关联是否通过肥胖来介导。
该样本由来自 LabMed 体力活动队列研究的 734 名青少年（349 名女孩）组成，年龄在 12-18 岁之间。2011 年（基线）和 2013 年（2 年随访）测量了感兴趣的变量。CRF 通过 20 米穿梭跑测试评估。根据标准程序评估体重指数、腰围、体脂百分比、青春期状态和静息血压。进行了自举中介分析程序，置信区间（CI）不包括零的间接效应（IE）被认为具有统计学意义。
在校正潜在混杂因素后，体重指数作为 CRF 与收缩压（IE= -0.023；CI= -0.039；-0.009）、脉压（IE= -0.023；CI= -0.034；-0.012）和乘积压力（IE= -2.839；CI= -5.329；-0.340）之间关系的中介。腰围作为收缩压（IE= -0.019；CI= -0.033；-0.005）、脉压（IE= -0.017；CI= -0.028；-0.007）和乘积压力（IE= -3.793；CI= -6.097；-1.689）的中介也得到了类似的结果。同样，体脂百分比介导了以下关联：收缩压（IE= -0.029；CI= -0.048；-0.010）、脉压（IE= -0.027；CI= -0.041；-0.013）和乘积压力（IE= -4.280；CI= -7.488；-1.264）。
肥胖症在青少年时期心肺适能与血压之间的关联中起中介作用。因此，在整个青春期，保持最佳的 CRF 和体脂水平都很重要，以维持正常的血压范围。
