Department of Bipolar Disorder, Tianjin Anding Hospital, Tianjin, China.
Department of Cardiology, Chest Hospital of Tianjin, Tianjin, China.
Brain Behav. 2020 Dec;10(12):e01885. doi: 10.1002/brb3.1885. Epub 2020 Oct 12.
Our study was designed to examine the relationship between Brain-Derived Neurotrophic Factor (BDNF) genotypes (rs6265, Val66Met), BDNF plasma levels, and cognitive impairment in Chinese patients with panic disorder (PD).
Total 85 patients with PD and 91 healthy controls finally completed all assessments. The severity of panic symptoms and whole anxiety of PD was measured by Panic Disorder Severity Scale-Chinese Version (PDSS-CV) and Hamilton Anxiety Scale (HAMA-14). Montreal Cognitive Assessment (MoCA) and some neurocognitive measures were conducted to evaluate the cognitive performance. All participants were detected for the plasma BDNF levels and BDNF Val66Met polymorphism before assessment and treatment.
No significant differences were found in the BDNF allele frequencies and the BDNF genotype distributions between healthy controls and PD patients. BDNF Met/Met genotype was associated with lower BDNF plasma levels in PD patients, and PD patients with BDNF Met/Met genotype had the lower scores in the attention and speed of processing domains compared to those with Val/Val and Met/Val genotype (p's < .05). Among PD patients, the BDNF plasma levels showed moderate positive correlations with Stroop interference (r = .60, p < .001). Using the MoCA data, the BDNF plasma levels were correlated with delayed memory (r = .50, p < .001), verbal learning (r = .45, p < .001), and total scores of MoCA (r = .51, p < .001).
The BDNF Met/Met genotype may be associated with lower BDNF plasma levels and cognitive impairments in PD patients.
本研究旨在探讨脑源性神经营养因子（BDNF）基因型（rs6265，Val66Met）、BDNF 血浆水平与中国惊恐障碍（PD）患者认知障碍的关系。
共有 85 例 PD 患者和 91 名健康对照者最终完成了所有评估。采用惊恐障碍严重程度评定量表-中文版（PDSS-CV）和汉密尔顿焦虑量表（HAMA-14）评估惊恐症状严重程度和整体焦虑程度。采用蒙特利尔认知评估量表（MoCA）和一些神经认知测试评估认知表现。所有参与者在评估和治疗前均检测血浆 BDNF 水平和 BDNF Val66Met 多态性。
健康对照组与 PD 患者之间 BDNF 等位基因频率和 BDNF 基因型分布无显著差异。BDNF Met/Met 基因型与 PD 患者 BDNF 血浆水平较低有关，与 Val/Val 和 Met/Val 基因型相比，BDNF Met/Met 基因型的 PD 患者在注意力和处理速度领域的得分较低（p 值均<.05）。在 PD 患者中，BDNF 血浆水平与 Stroop 干扰呈中度正相关（r=60，p<0.001）。使用 MoCA 数据，BDNF 血浆水平与延迟记忆（r=50，p<0.001）、词语学习（r=45，p<0.001）和 MoCA 总分（r=51，p<0.001）相关。
BDNF Met/Met 基因型可能与 PD 患者 BDNF 血浆水平较低和认知障碍有关。
