Bender J G, Van Epps D E, Stewart C C
Comp Immunol Microbiol Infect Dis. 1987;10(2):79-91. doi: 10.1016/0147-9571(87)90001-4.
Myeloid cells are produced by the bone marrow from stem cells and progenitor cells. This review summarizes the current understanding of how this process is regulated. Regulation of progenitor cell proliferation and differentiation occurs in microenvironments present within the bone marrow as well as on the systemic level by the release of regulators into the circulation. The regulators of central importance to myelopoiesis are growth factors necessary for the proliferation and differentiation of progenitors. These growth factors have recently been characterized and studies indicate that there is a hierarchy of factors acting upon successive differentiation stages of progenitors. Endotoxin appears to be a major modulator of myeloid growth factor production. Other inhibitors of myelopoiesis are also discussed. Regulation of myelopoiesis therefore involves a balance between growth factor production and inhibition by other factors.
髓样细胞由骨髓中的干细胞和祖细胞产生。本综述总结了目前对这一过程如何受到调控的理解。祖细胞增殖和分化的调控发生在骨髓内的微环境中，以及通过将调节因子释放到循环系统中在全身水平上进行。对髓系造血至关重要的调节因子是祖细胞增殖和分化所必需的生长因子。这些生长因子最近已得到表征，研究表明，存在一系列作用于祖细胞连续分化阶段的因子。内毒素似乎是髓样生长因子产生的主要调节因子。还讨论了其他髓系造血抑制剂。因此，髓系造血的调控涉及生长因子产生与其他因子抑制之间的平衡。
