功能化苯并吡喃/香豆素衍生芳基的合成及其应用。
Synthesis of Functionalized Benzopyran/Coumarin-Derived Aryne Precursors and Their Applications.
机构信息
Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
出版信息
Org Lett. 2020 Nov 6;22(21):8505-8510. doi: 10.1021/acs.orglett.0c03106. Epub 2020 Oct 13.
An efficient synthetic method of benzopyran derivatives involving coumarins is disclosed. Gold-catalyzed benzopyran formation and subsequent aryne reactions enabled us to prepare a wide range of benzopyran derivatives by virtue of their good functional group tolerance and versatile transformability of aryne intermediates. The synthetic utility was showcased by a diarylnaphthopyran synthesis through this method and consecutive cross-coupling reactions.
本文公开了一种涉及香豆素的苯并吡喃衍生物的高效合成方法。金催化苯并吡喃的形成以及随后的芳基反应使我们能够通过其良好的官能团耐受性和芳基反应中间体的多功能转化性来制备广泛的苯并吡喃衍生物。通过这种方法和连续的交叉偶联反应，展示了合成实用性，合成了二芳基萘并吡喃。
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