Richard Vinitha, Kumar T R Santhosh, Pillai Radhakrishna M
Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695014, Kerala State, India.
Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695014, Kerala State, India.
Transl Oncol. 2021 Jan;14(1):100909. doi: 10.1016/j.tranon.2020.100909. Epub 2020 Oct 10.
At the onset, few cancer cells amidst the tumor bulk, identified as cancer stem cells (CSCs) or early disseminated cancer cells (eDCCs) are capable of survival post conventional therapy and persist as minimal residual disease (MRD). Metastatic subclones emerge both early and late in the life of primary tumor ensuing an ongoing regional clonal evolution of progenitor cells in metastatic and primary tumors. In the last decade, multiple studies proposed various identities of stem-like cells that undergo transitions to adapt to the changing microenvironment as the disease progresses. This review advocates with substantial evidence the dynamic model of tumor propagation by exploring the specific cell types, reversible phenotypic plasticity between the tumorigenic leader seeds and the supporting follower cancer cells both in circulation and in solid tissue to accurately decipher tumor promoting clones and its role in metastatic dissemination and tumor re-growth. (142 words).
起初，肿瘤主体中的少数癌细胞，即被鉴定为癌症干细胞（CSCs）或早期播散癌细胞（eDCCs），能够在传统治疗后存活并作为微小残留病（MRD）持续存在。转移亚克隆在原发性肿瘤的早期和晚期均会出现，导致转移瘤和原发性肿瘤中祖细胞持续进行区域克隆进化。在过去十年中，多项研究提出了多种干细胞样细胞的身份，这些细胞会随着疾病进展发生转变以适应不断变化的微环境。本综述通过探索特定细胞类型、循环中和实体组织中致瘤主导种子细胞与支持性从属癌细胞之间可逆的表型可塑性，以准确解读促进肿瘤的克隆及其在转移播散和肿瘤再生长中的作用，有力地支持了肿瘤增殖的动态模型。（142字）
