Araiza Victor Hugo Del Rio, Mendoza Mariana Segovia, Castro Karen Elizabeth Nava, Cruz Samira Munoz, Rueda Karina Chavez, de Leon Carmen Tlazoelteot Gomez, Morales Montor Jorge
Departamento de Parasitologia, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, CP 04510, Ciudad de Mexico, Mexico.
Departamento de Farmacologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, CP 04510, Ciudad de Mexico, Mexico.
Front Biosci (Landmark Ed). 2021 Jan 1;26(2):346-362. doi: 10.2741/4897.
Bisphenol A (BPA) is an endocrine-disruptor compound that exhibits estrogenic activity. BPA is used in the production of materials such as polycarbonate plastics, epoxy resins and dental sealants. Whereas, the endocrine modulating activity of BPA and its effects on reproductive health have been widely studied, its effects on the function of the immune system are poorly characterized. This might be attributable to the different BPA doses used in a diversity of animal models. Moreover, most studies of the effect of BPA on the immune response are limited to in vitro and in vivo studies that have focused primarily on the impact of BPA on the number and proportion of immune cell populations, without evaluating its effects on immune function in response to an antigenic challenge or infectious pathogens. In this review, we discuss the current literature on the effects of BPA on the function of immune system that potentially increases the susceptibility to infections by the virtue of acting as a pro-inflammatory molecule. Thus, it appears that BPA, while by such an impact might be useful in the control of certain disease states that are helped by an inflmmatory response, it can worsen the prognosis of diseases that are adversely affected by inflammation.
双酚A（BPA）是一种具有雌激素活性的内分泌干扰化合物。BPA用于生产聚碳酸酯塑料、环氧树脂和牙科密封剂等材料。尽管BPA的内分泌调节活性及其对生殖健康的影响已得到广泛研究，但其对免疫系统功能的影响却知之甚少。这可能归因于在多种动物模型中使用的BPA剂量不同。此外，大多数关于BPA对免疫反应影响的研究仅限于体外和体内研究，这些研究主要关注BPA对免疫细胞群体数量和比例的影响，而没有评估其对抗抗原刺激或感染性病原体时免疫功能的影响。在这篇综述中，我们讨论了关于BPA对免疫系统功能影响的当前文献，BPA可能通过作为促炎分子而增加感染易感性。因此，虽然BPA通过这种影响可能有助于控制某些由炎症反应辅助的疾病状态，但它会恶化那些受炎症不利影响的疾病的预后。
