Molinari Francesco, Franco Gianluca Antonio, Tranchida Nicla, Di Paola Rosanna, Cordaro Marika
Department of Veterinary Sciences, University of Messina, Viale SS Annunziata, 98168 Messina, Italy.
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, 98166 Messina, Italy.
Int J Mol Sci. 2024 Nov 22;25(23):12540. doi: 10.3390/ijms252312540.
Endocrine-disrupting chemicals (EDCs) are a growing health hazard for humankind and respiratory health in particular. Such chemical compounds are present in the environment and food and may interfere with physiological processes through interference with functions of the endocrine system, making humans more susceptible to various types of diseases. This review aims to discuss the effects of EDCs on the respiratory system. Exposure to EDCs during fetal development and adulthood increases susceptibility to respiratory diseases such as asthma, COPD, and pulmonary fibrosis. EDCs are both multiple and complex in the ways they can act. Indeed, these chemicals may induce oxidative stress, modify cell proliferation and differentiation, interfere with tissue repair, and modulate the inflammatory response. Moreover, EDCs may also break the integrity of the blood-air barrier, allowing noxious substances to penetrate into the lung and thus enhancing the opportunity for infection. In conclusion, the scientific evidence available tends to indicate that EDCs exposure is strongly linked to the initiation of respiratory disease. Further research will be important in discovering the underlying molecular mechanisms and devising preventive and therapeutic measures.
内分泌干扰化学物质（EDCs）对人类健康，尤其是呼吸系统健康构成了日益严重的威胁。此类化合物存在于环境和食物中，可能通过干扰内分泌系统的功能来干扰生理过程，使人类更容易患上各种疾病。本综述旨在探讨EDCs对呼吸系统的影响。在胎儿发育和成年期接触EDCs会增加患哮喘、慢性阻塞性肺疾病（COPD）和肺纤维化等呼吸系统疾病的易感性。EDCs的作用方式多样且复杂。事实上，这些化学物质可能会诱导氧化应激、改变细胞增殖和分化、干扰组织修复并调节炎症反应。此外，EDCs还可能破坏气血屏障的完整性，使有害物质渗入肺部，从而增加感染的机会。总之，现有科学证据倾向于表明，接触EDCs与呼吸系统疾病的发病密切相关。进一步的研究对于发现潜在的分子机制以及制定预防和治疗措施至关重要。
