Department of Medical Microbiology and Immunology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Viruses. 2020 Oct 9;12(10):1148. doi: 10.3390/v12101148.
Hepatitis E virus (HEV) (family ) is one of the most common human pathogens, causing acute hepatitis and an increasingly recognized etiological agent in chronic hepatitis and extrahepatic manifestations. Recent studies reported that not only are the classical members of the species (HEV-A) pathogenic to humans but a genetically highly divergent rat origin hepevirus (HEV-C1) in species (HEV-C) is also able to cause zoonotic infection and symptomatic disease (hepatitis) in humans. This review summarizes the current knowledge of hepeviruses in rodents with special focus of rat origin HEV-C1. Cross-species transmission and genetic diversity of HEV-C1 and confirmation of HEV-C1 infections and symptomatic disease in humans re-opened the long-lasting and full of surprises story of HEV in human. This novel knowledge has a consequence to the epidemiology, clinical aspects, laboratory diagnosis, and prevention of HEV infection in humans.
戊型肝炎病毒 (HEV)（属）是最常见的人类病原体之一，可引起急性肝炎，并日益被认为是慢性肝炎和肝外表现的病因。最近的研究报告称，不仅该物种的经典成员（HEV-A）对人类具有致病性，而且种属（HEV-C）中具有高度遗传差异的大鼠起源的庚型肝炎病毒 (HEV-C1) 也能够导致人畜共患感染和人类的症状性疾病（肝炎）。本文综述了啮齿动物中庚型肝炎病毒的最新知识，特别关注大鼠起源的 HEV-C1。HEV-C1 的跨种传播和遗传多样性，以及在人类中确认 HEV-C1 感染和症状性疾病，重新开启了戊型肝炎病毒在人类中持久而充满惊喜的故事。这一新知识对戊型肝炎病毒在人类中的流行病学、临床方面、实验室诊断和预防具有重要意义。
