Zhang Huilin, Lu Bingjian
Department of Surgical Pathology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310002, Zhejiang Province, China.
Department of Surgical Pathology and Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310002, Zhejiang Province, China.
Cancers (Basel). 2020 Oct 11;12(10):2926. doi: 10.3390/cancers12102926.
Chemoresistance and metastasis are the main causes of treatment failure and unfavorable outcome in cancers. There is a pressing need to reveal their mechanisms and to discover novel therapy targets. Autophagy is composed of a cascade of steps controlled by different autophagy-related genes (ATGs). Accumulating evidence suggests that dysregulated autophagy contributes to chemoresistance and metastasis via competing endogenous RNA (ceRNA) networks including lncRNAs and circRNAs. ceRNAs sequester the targeted miRNA expression to indirectly upregulate ATGs expression, and thereof participate in autophagy-mediated chemoresistance and metastasis. Here, we attempt to summarize the roles of ceRNAs in cancer chemoresistance and metastasis through autophagy regulation.
化疗耐药和转移是癌症治疗失败和预后不良的主要原因。迫切需要揭示其机制并发现新的治疗靶点。自噬由一系列由不同自噬相关基因（ATG）控制的步骤组成。越来越多的证据表明，失调的自噬通过包括长链非编码RNA（lncRNA）和环状RNA（circRNA）在内的竞争性内源性RNA（ceRNA）网络促进化疗耐药和转移。ceRNA隔离靶向的miRNA表达以间接上调ATG表达，从而参与自噬介导的化疗耐药和转移。在此，我们试图总结ceRNA通过自噬调节在癌症化疗耐药和转移中的作用。
