高压氧治疗严重创伤性脑损伤：一项随机试验。
Hyperbaric oxygen for severe traumatic brain injury: a randomized trial.
机构信息
Department of Emergency, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China.
Department of Neurosurgery, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China.
出版信息
J Int Med Res. 2020 Oct;48(10):300060520939824. doi: 10.1177/0300060520939824.
OBJECTIVE
The present study aimed to explore the effects of hyperbaric oxygen therapy on the prognosis and neurological function of patients with severe traumatic brain injury.
METHODS
A prospective study was carried out in 88 patients diagnosed with severe brain injury at our hospital and they were enrolled as research participants and randomly assigned to control and experimental groups (n = 44 per group) using a random number table method. Both groups underwent routine treatment. Patients in the experimental group were administered hyperbaric oxygen therapy approximately 1 week after admission when their vital signs had stabilized.
RESULTS
No significant intergroup differences were observed in the Glasgow Coma Scale (GCS) and U.S. National Institutes of Health Stroke Scale (NIHSS) scores before treatment. However, after oxygen treatment, compared with the control group, the experimental group showed higher GCS and lower NIHSS scores. The GCS score at admission, tracheotomy status, and first hyperbaric oxygen therapy duration were independent prognostic factors in patients with severe traumatic brain injury.
CONCLUSION
Hyperbaric oxygen therapy may promote recovery of neurological function and improve the cognitive function and prognosis of patients with severe traumatic brain injury.
目的
本研究旨在探讨高压氧治疗对重症颅脑损伤患者预后及神经功能的影响。
方法
采用前瞻性研究方法，选取我院收治的 88 例确诊为重型颅脑损伤的患者作为研究对象，采用随机数字表法将其分为对照组和实验组（每组 44 例）。两组均进行常规治疗。实验组患者在生命体征稳定后约入院 1 周时接受高压氧治疗。
结果
治疗前两组患者的格拉斯哥昏迷量表（GCS）和美国国立卫生研究院卒中量表（NIHSS）评分无明显组间差异。然而，与对照组相比，接受氧疗后实验组的 GCS 评分更高，NIHSS 评分更低。重型颅脑损伤患者入院时的 GCS 评分、气管切开状态和首次高压氧治疗持续时间是独立的预后因素。
结论
高压氧治疗可能促进神经功能恢复，改善重症颅脑损伤患者的认知功能和预后。
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