Lin Chun-Chieh, Chen Hsing-Yu, Tseng Chu-Yao, Yang Chien-Chung
Division of Acupuncture and Traumatology, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan 33378, Taiwan.
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 330036, Taiwan.
Healthcare (Basel). 2023 Aug 11;11(16):2267. doi: 10.3390/healthcare11162267.
Traumatic brain injury (TBI) causes cognitive dysfunction and long-term impairments. This study aims to examine the effectiveness of acupuncture on the recovery of consciousness in TBI patients. This is a retrospective, multi-institutional cohort study. We enrolled patients with newly diagnosed TBI from 1 January 2007 to 3 August 2021, aged 20 years and older, from the Chang Gung Research Database (CGRD). The outcome was defined based on the difference between the first and last Glasgow Coma Scale (GCS). A total of 2163 TBI patients were analyzed, and 237 (11%) received acupuncture in the treatment period. Generally, the initial GCS was lower in the acupuncture users (11 vs. 14). For the results of our study, a higher proportion of acupuncture patients achieved significant improvement (GCS differences ≥ 3) compared to non-acupuncture users (46.0% vs. 22.4%, -value < 0.001). The acupuncture users had a 2.11 times higher chance of achieving a significant improvement when considering all assessable covariates (adjusted odds ratio (aOR) 2, 11, 95% confidence interval [CI]: 1.31-3.40; -value = 0.002). Using 1:1 propensity score matching (PSM), the acupuncture users still had better outcomes than the non-acupuncture users (45.3% vs. 32.9%, -value = 0.020). In conclusion, this study suggests that acupuncture treatment may be beneficial for TBI patients.
创伤性脑损伤（TBI）会导致认知功能障碍和长期损伤。本研究旨在探讨针刺对TBI患者意识恢复的有效性。这是一项回顾性、多机构队列研究。我们从长庚研究数据库（CGRD）中纳入了2007年1月1日至2021年8月3日新诊断为TBI的20岁及以上患者。结局根据首次和末次格拉斯哥昏迷量表（GCS）的差异来定义。共分析了2163例TBI患者，其中237例（11%）在治疗期间接受了针刺治疗。一般来说，针刺治疗组患者的初始GCS较低（11分对14分）。在我们的研究结果中，与未接受针刺治疗的患者相比，接受针刺治疗的患者中有更高比例实现了显著改善（GCS差异≥3）（46.0%对22.4%，P值<0.001）。在考虑所有可评估的协变量时，接受针刺治疗的患者实现显著改善的可能性高2.11倍（调整后的优势比（aOR）为2.11，95%置信区间[CI]：1.31-3.40；P值=0.002）。使用1:1倾向评分匹配（PSM），接受针刺治疗的患者仍比未接受针刺治疗的患者有更好的结局（45.3%对32.9%，P值=0.020）。总之，本研究表明针刺治疗可能对TBI患者有益。
