Roche E, Aniento F, Knecht E, Grisolía S
FEBS Lett. 1987 Sep 14;221(2):231-5. doi: 10.1016/0014-5793(87)80931-6.
Intracellular protein breakdown could be regulated at the substrate level by changes in the environment. Under in vitro conditions, ATP increases the proteolytic susceptibility of several mitochondrial and cytosolic proteins, while 2,3-bisphosphoglycerate not only has the opposite effect but also prevents the ATP-stimulated proteolysis. ATP and 2,3-bisphosphoglycerate, present at relatively high levels in many tissues, provide a good model of environmental components that may influence intracellular proteolysis.
细胞内蛋白质分解可在底物水平上受环境变化的调节。在体外条件下，ATP可增加几种线粒体和胞质蛋白质的蛋白水解敏感性，而2,3-二磷酸甘油酸不仅具有相反的作用，还可阻止ATP刺激的蛋白水解。ATP和2,3-二磷酸甘油酸在许多组织中含量相对较高，为可能影响细胞内蛋白水解的环境成分提供了一个良好的模型。
