Roche E, Knecht E, Grisolía S
Biochem Biophys Res Commun. 1987 Feb 13;142(3):680-7. doi: 10.1016/0006-291x(87)91468-9.
2,3-bisphosphoglycerate at physiological concentration similar to that found in many tissues protects effectively ornithine transcarbamoylase (OTC) from proteolytic inactivation by broken lysosomes. 2,3-bisphosphoglycerate protects also many other mitochondrial and cytosolic proteins, such as glutamate dehydrogenase (GDH) an glyceraldehyde-3-phosphate dehydrogenase (GAPDH), from proteolysis by broken lysosomes and other proteases. It is, thus, suggested that 2,3-bisphosphoglycerate may play an important role in the control of the degradative rates of some proteins, which may explain its high concentration in certain cells.
生理浓度与许多组织中相似的2,3-二磷酸甘油酸能有效保护鸟氨酸转氨甲酰酶（OTC）不被破裂的溶酶体蛋白水解失活。2,3-二磷酸甘油酸还能保护许多其他线粒体和胞质蛋白，如谷氨酸脱氢酶（GDH）和甘油醛-3-磷酸脱氢酶（GAPDH），使其不被破裂的溶酶体及其他蛋白酶水解。因此，有人提出2,3-二磷酸甘油酸可能在控制某些蛋白质的降解速率方面发挥重要作用，这或许可以解释其在某些细胞中的高浓度现象。
