Department of Colorectal and Anal Surgery, Shengzhou People's Hospital, Shengzhou, Zhejiang, China.
Int J Biol Markers. 2020 Dec;35(4):71-79. doi: 10.1177/1724600820944408. Epub 2020 Oct 14.
polymorphisms may affect predisposition of cancer, but the results of published studies remain inconclusive. Therefore, the authors conducted this meta-analysis to more robustly assess relationships between polymorphisms and the predisposition of cancer by pooling the findings of published studies.
A comprehensive literature search of PubMed, Embase, Web of Science, Wanfang, and CNKI was endorsed by the authors to identify eligible studies; 17 studies were finally found to be eligible for pooled meta-analysis.
The pooled meta-analysis results showed that genotypic frequencies of the rs4809960 polymorphism among cancerous patients and controls of Caucasian ethnicity differed significantly, and genotypic frequencies of the rs6022999 polymorphism among cancerous patients and controls of Asian ethnicity also differed significantly. Moreover, we found that genotypic frequencies of the rs2585428 polymorphism among patients with prostate cancer and controls differed significantly, and genotypic frequencies of the rs6068816 polymorphism among patients with prostate cancer/breast cancer and controls also differed significantly.
This meta-analysis suggests that the rs4809960 polymorphism may affect the predisposition of cancer in Caucasians, and the rs6022999 polymorphism may affect the predisposition of cancer in Asians. Moreover, the rs2585428 polymorphism may affect the predisposition of prostate cancer, while the rs6068816 polymorphism may affect the predisposition of prostate cancer and breast cancer.
多态性可能会影响癌症的易感性，但已发表的研究结果仍存在争议。因此，作者进行了这项荟萃分析，通过汇总已发表研究的结果，更有力地评估了多态性与癌症易感性之间的关系。
作者进行了全面的文献检索，检索了 PubMed、Embase、Web of Science、万方和中国知网，以确定符合条件的研究；最终有 17 项研究符合荟萃分析的纳入标准。
荟萃分析结果表明，高加索人群癌症患者和对照组中 rs4809960 多态性的基因型频率存在显著差异，亚洲人群癌症患者和对照组中 rs6022999 多态性的基因型频率也存在显著差异。此外，我们还发现，前列腺癌患者和对照组中 rs2585428 多态性的基因型频率存在显著差异，前列腺癌/乳腺癌患者和对照组中 rs6068816 多态性的基因型频率也存在显著差异。
这项荟萃分析表明，rs4809960 多态性可能会影响高加索人群癌症的易感性，rs6022999 多态性可能会影响亚洲人群癌症的易感性。此外，rs2585428 多态性可能会影响前列腺癌的易感性，而 rs6068816 多态性可能会影响前列腺癌和乳腺癌的易感性。
