Department of Clinical Laboratory Medicine and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, PR China.
Center of Reproductive Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, PR China.
Pathol Res Pract. 2018 Jan;214(1):53-63. doi: 10.1016/j.prp.2017.11.014. Epub 2017 Nov 21.
Published data have shown that vitamin D may have a protective effect on cancer development. CYP24A1, the main enzyme responsible for the degradation of active vitamin D, plays an important role in many cancer related cellular processes. Up to now, relationships between CYP24A1 polymorphisms and cancer susceptibility have been widely investigated, whereas the results are inconsistent. The aim of present meta-analysis was to explore the associations between CYP24A1 polymorphisms and cancer susceptibility.
We searched on EMBASE, Web of Science, PubMed and China National Knowledge Infrastructure (CNKI) electronic databases (up to July 1, 2017) for relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to make the evaluation clear.
Twenty-nine studies published in eight publications involving 20,593 cases and 25,458 controls were included. Five CYP24A1 gene polymorphisms were evaluated: rs2181874, rs2585428, rs4809960, rs6022999, and rs6068816. Our analyses suggested that rs2585428 and rs4809960 polymorphisms were significantly associated with overall cancer risk. Stratification analyses of ethnicity indicated that rs2585428 and rs4809960 polymorphisms decreased the risk of cancer among Caucasians. When studies were stratified by cancer type, our results indicated that rs2585428 significantly decreased the risk of pancreas cancer, while rs4809960 significantly decreased the risk of breast cancer. There were no associations of rs2181874, rs6022999, or rs6068816 with overall cancer risks.
Associations between CYP24A1 polymorphisms and cancer risks were examined, and additional multi-center studies with large samples are necessary to validate our results.
已发表的数据表明，维生素 D 可能对癌症的发生具有保护作用。CYP24A1 是负责降解活性维生素 D 的主要酶，它在许多与癌症相关的细胞过程中发挥着重要作用。迄今为止，CYP24A1 多态性与癌症易感性之间的关系已被广泛研究，但结果并不一致。本荟萃分析的目的是探讨 CYP24A1 多态性与癌症易感性之间的关系。
我们在 EMBASE、Web of Science、PubMed 和中国知网（CNKI）电子数据库（截至 2017 年 7 月 1 日）中进行了相关研究的检索。计算比值比（OR）和 95%置信区间（CI）以明确评估结果。
共纳入了 8 篇文献中的 29 项研究，包括 20593 例病例和 25458 例对照。评估了 CYP24A1 基因的 5 种多态性：rs2181874、rs2585428、rs4809960、rs6022999 和 rs6068816。我们的分析表明，rs2585428 和 rs4809960 多态性与总体癌症风险显著相关。按种族进行分层分析表明，rs2585428 和 rs4809960 多态性降低了白种人患癌症的风险。按癌症类型进行分层分析时，我们的结果表明 rs2585428 显著降低了胰腺癌的风险，而 rs4809960 显著降低了乳腺癌的风险。rs2181874、rs6022999 或 rs6068816 与总体癌症风险均无关联。
我们研究了 CYP24A1 多态性与癌症风险之间的关系，需要进行更多的多中心大样本研究来验证我们的结果。
