Aix-Marseille Université, CNRS, IBDM, Marseille, France.
Aix-Marseille Université, CNRS, IBDM, Marseille, France.
Trends Neurosci. 2020 Dec;43(12):998-1010. doi: 10.1016/j.tins.2020.09.007. Epub 2020 Oct 10.
Behavior is the neuronally controlled, voluntary or involuntary response of an organism to its environment. An increasing body of evidence indicates that microbes, which live closely associated with animals or in their immediate surroundings, significantly influence animals' behavior. The extreme complexity of the nervous system of animals, combined with the extraordinary microbial diversity, are two major obstacles to understand, at the molecular level, how microbes modulate animal behavior. In this review, we discuss recent advances in dissecting the impact that bacteria have on the nervous system of two genetically tractable invertebrate models, Drosophila melanogaster and Caenorhabditis elegans.
行为是生物体对其环境的神经控制的、自愿或非自愿的反应。越来越多的证据表明，与动物密切相关或生活在其周围的微生物会显著影响动物的行为。动物神经系统的极端复杂性，加上微生物的巨大多样性，是从分子水平理解微生物如何调节动物行为的两个主要障碍。在这篇综述中，我们讨论了在剖析细菌对两种遗传上可操作的无脊椎动物模型——黑腹果蝇和秀丽隐杆线虫的神经系统的影响方面的最新进展。
