Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
J Clin Endocrinol Metab. 2021 Jan 1;106(1):201-210. doi: 10.1210/clinem/dgaa740.
Dietary fiber intake may relate to bone health.
To investigate whether dietary fiber intake is associated with bone mineral density (BMD), and the modification effect of genetic variations related to gut microbiota-derived short-chain fatty acids (SCFAs).
The associations of dietary fiber intake with estimated BMD derived from heel ultrasound and fractures were assessed in 224 630 and 384 134 participants from the UK Biobank.
UK Biobank.
Estimated BMD derived from heel ultrasound.
Higher dietary fiber intake (per standard deviation) was significantly associated with higher heel-BMD (β [standard error] = 0.0047 [0.0003], P = 1.10 × 10-54). Similarly significant associations were observed for all the fiber subtypes including cereal, fruit (dried and raw), and vegetable (cooked and raw) (all P < .05). A positive association was found in both women and men but more marked among men except for dietary fiber in cooked vegetables (all Pinteraction < .05). A protective association was found between dietary fiber intake and hip fracture (hazard ratio, 95% confidence interval: 0.94, 0.89-0.99; P = 3.0 × 10-2). In addition, the association between dietary fiber and heel BMD was modified by genetically determined SCFA propionate production (Pinteraction = 5.1 × 10-3). The protective association between dietary fiber and heel BMD was more pronounced among participants with lower genetically determined propionate production.
Our results indicate that greater intakes of total dietary fiber and subtypes from various food sources are associated with higher heel-BMD. Participants with lower genetically determined propionate production may benefit more from taking more dietary fiber.
膳食纤维的摄入量可能与骨骼健康有关。
研究膳食纤维的摄入量是否与骨矿物质密度（BMD）有关，以及与肠道微生物衍生的短链脂肪酸（SCFA）相关的遗传变异的修饰作用。
在英国生物库的 224630 名和 384134 名参与者中，评估了膳食纤维摄入量与足跟超声估计的 BMD 以及骨折之间的关联。
英国生物库。
足跟超声估计的 BMD。
膳食纤维摄入量（每标准差）较高与足跟-BMD 较高显著相关（β[标准误差]=0.0047[0.0003]，P=1.10×10-54）。同样显著的关联也见于所有纤维亚型，包括谷物、水果（干和生）和蔬菜（熟和生）（均 P<0.05）。这种正相关在女性和男性中均存在，但在男性中更为显著，除了熟蔬菜中的膳食纤维（所有 P 交互<0.05）。膳食纤维摄入量与髋部骨折之间存在保护性关联（危险比，95%置信区间：0.94，0.89-0.99；P=3.0×10-2）。此外，膳食纤维与足跟 BMD 的关联受遗传决定的 SCFA 丙酸盐产生的修饰（P 交互=5.1×10-3）。在遗传决定的丙酸盐产生较低的参与者中，膳食纤维与足跟 BMD 之间的保护性关联更为显著。
我们的研究结果表明，来自各种食物来源的总膳食纤维和亚型的摄入量较高与足跟-BMD 较高相关。遗传决定的丙酸盐产生较低的参与者可能从摄入更多膳食纤维中获益更多。
