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一名老年女性因度洛西汀过量导致急性重度低钠血症

Acute Severe Hyponatremia Induced by a Duloxetine Overdose in an Elderly Woman.

作者信息

Oliver Wesley D, D'Angelo Ryan, Gonzales Jeffrey, Wilson Tracey, Millstein Leah S

机构信息

Emergency Medicine, University of Maryland Medical Center, Baltimore, USA.

Cardiology, Thomas Jefferson University Hospital, Philadelphia, USA.

出版信息

Cureus. 2020 Sep 8;12(9):e10318. doi: 10.7759/cureus.10318.

DOI:10.7759/cureus.10318
PMID:33052279
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7546372/
Abstract

We report a case of acute severe hyponatremia within 24 hours after a duloxetine overdose. An 82-year-old woman presented to the ED after ingesting duloxetine and diltiazem. She became hemodynamically unstable due to the diltiazem overdose and was appropriately resuscitated. During hospitalization she experienced hyponatremia consistent with syndrome of inappropriate antidiuretic hormone (SIADH). Based on the observations we concluded there was a probable relationship between the hyponatremia and the duloxetine overdose. Clinicians should monitor patients' electrolytes for acute disturbances after an overdose of duloxetine.

摘要

我们报告了一例度洛西汀过量服用后24小时内发生急性重度低钠血症的病例。一名82岁女性在服用度洛西汀和地尔硫䓬后被送往急诊室。由于地尔硫䓬过量，她出现血流动力学不稳定，并得到了适当的复苏。住院期间，她出现了与抗利尿激素分泌不当综合征（SIADH）相符的低钠血症。基于这些观察结果，我们得出结论，低钠血症与度洛西汀过量之间可能存在关联。临床医生在度洛西汀过量后应监测患者电解质有无急性紊乱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/7546372/6824c7bc2a3b/cureus-0012-00000010318-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/7546372/6824c7bc2a3b/cureus-0012-00000010318-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/7546372/6824c7bc2a3b/cureus-0012-00000010318-i01.jpg

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本文引用的文献

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Duloxetine-Induced Hyponatremia in an Elderly Male Patient with Treatment-Refractory Major Depressive Disorder.度洛西汀致一名患有难治性重度抑郁症的老年男性患者低钠血症
Case Rep Psychiatry. 2019 May 13;2019:4109150. doi: 10.1155/2019/4109150. eCollection 2019.
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Acute Hyponatremia Resulting from Duloxetine-induced Syndrome of Inappropriate Antidiuretic Hormone Secretion.度洛西汀诱发抗利尿激素分泌异常综合征导致的急性低钠血症
Intern Med. 2019 Jul 1;58(13):1939-1942. doi: 10.2169/internalmedicine.2346-18. Epub 2019 Feb 25.
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Rapid-onset hyponatremia and delirium following duloxetine treatment for postherpetic neuralgia: Case report and literature review.
度洛西汀治疗带状疱疹后神经痛后快速发作的低钠血症和谵妄：病例报告及文献综述
Medicine (Baltimore). 2018 Nov;97(46):e13178. doi: 10.1097/MD.0000000000013178.
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Hyponatremia Induced by Duloxetine: A Case Report.度洛西汀诱发低钠血症：一例报告
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Antidepressant-Induced Hyponatremia in Older Adults.老年人抗抑郁药所致低钠血症
Consult Pharm. 2016 Mar;31(3):139-50. doi: 10.4140/TCP.n.2016.139.
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Duloxetine induced hyponatremia.度洛西汀诱发低钠血症。
Indian J Nephrol. 2015 Jul-Aug;25(4):259. doi: 10.4103/0971-4065.151352.
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Syndrome of inappropriate antidiuretic hormone secretion: a story of duloxetine-induced hyponatraemia.抗利尿激素分泌不当综合征：一则关于度洛西汀诱发低钠血症的病例
BMJ Case Rep. 2015 Apr 24;2015:bcr2014208037. doi: 10.1136/bcr-2014-208037.
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Disorders of plasma sodium--causes, consequences, and correction.血浆钠紊乱——病因、后果及纠正
N Engl J Med. 2015 Jan 1;372(1):55-65. doi: 10.1056/NEJMra1404489.
9
Duloxetine-induced hyponatremia in an elderly patient treated with thiazide diuretics.在一名接受噻嗪类利尿剂治疗的老年患者中，度洛西汀诱发低钠血症。
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