Rutherfoord G S, Davies A G
Histopathology. 1987 Aug;11(8):775-87. doi: 10.1111/j.1365-2559.1987.tb01882.x.
Six chordomas (three classic and three chondroid) were examined ultrastructurally and with a panel of monoclonal antibodies. The three classic tumours showed the presence of desmosomes and intermediate filaments on electron microscopy, findings which gave a direct positive correlation when the tumours were stained with monoclonal antibodies against low molecular weight cytokeratin proteins. These results suggest that chordomas are essentially epithelial neoplasms and underline the fact that monoclonal antibodies to cytokeratins cannot be used in the differential diagnosis of classic chordoma vs carcinoma. Furthermore, the epithelial characteristics are lost as the tumour undergoes chondroid differentiation.
对6例脊索瘤（3例经典型和3例软骨样型）进行了超微结构检查，并使用一组单克隆抗体进行检测。3例经典型肿瘤在电子显微镜下显示有桥粒和中间丝，当用针对低分子量细胞角蛋白的单克隆抗体对肿瘤进行染色时，这些发现呈现出直接的正相关。这些结果表明脊索瘤本质上是上皮性肿瘤，并强调了细胞角蛋白单克隆抗体不能用于经典型脊索瘤与癌的鉴别诊断这一事实。此外，随着肿瘤发生软骨样分化，上皮特征会丧失。
