Niwa J, Hashi K, Minase T
Department of Neurosurgery, Sapporo Medical University.
Noshuyo Byori. 1994;11(1):15-21.
Immunohistochemical and electron microscopic studies were carried out on 9 cases of intracranial chordomas. Three of them were typical chordomas and 6 were chondroid chordomas. Immunohistochemically, both typical chordomas and chondroid chordomas were positively stained for cytokeratin and epithelial membrane antigen. Chondroid chordomas were stained for vimentin with moderate intensity whereas typical chordomas were only slightly stained. In comparison to typical chordomas, the chondroid chordomas had relatively few desmosomes and intermediate filaments. These findings suggest that intracranial chordomas are of mixed epithelial-mesenchymal nature, and that chondroid chordomas have a predominant mesenchymal character as compared to typical chordomas.
对9例颅内脊索瘤进行了免疫组织化学和电子显微镜研究。其中3例为典型脊索瘤，6例为软骨样脊索瘤。免疫组织化学显示，典型脊索瘤和软骨样脊索瘤的细胞角蛋白和上皮膜抗原均呈阳性染色。软骨样脊索瘤波形蛋白呈中度染色，而典型脊索瘤仅轻度染色。与典型脊索瘤相比，软骨样脊索瘤的桥粒和中间丝相对较少。这些发现表明颅内脊索瘤具有上皮-间充质混合性质，且与典型脊索瘤相比，软骨样脊索瘤具有更显著的间充质特征。
