Olsen B S, Holck S
Histopathology. 1987 Aug;11(8):843-9. doi: 10.1111/j.1365-2559.1987.tb01887.x.
A series of 237 appendices was studied immunohistochemically for neurogenous hyperplasia. This was observed in 195 cases. It was possible to trace a continuum from appendices with intact lumens, featuring intramucosal neurogenous hyperplasia often with co-existent submucosal and muscular nerve growth, to obliterated specimens whose axial portions were composed of varying proportions of nerve tangles and fibrous tissue. Predominantly fibrotic specimens were considered as end-stages of this process. Stromal, argyrophilic cells lying amidst the nerve elements were prominent in the early, non-obliterated cases; their number decreased in the obliterated nerve rich specimens and such cells became inapparent in the late fibrotic stage. Repeated minimal subclinical attacks of inflammation are thought to trigger this lesion.
对237份阑尾标本进行免疫组织化学研究以检测神经源性增生。在195例标本中观察到了这种情况。可以追踪到一个连续过程，从管腔完整的阑尾，其特征为黏膜内神经源性增生，常伴有黏膜下和肌层神经生长，到管腔闭塞的标本，其轴向部分由不同比例的神经缠结和纤维组织组成。主要为纤维化的标本被认为是该过程的终末期。在早期未闭塞的病例中，位于神经成分之间的基质嗜银细胞很突出；在神经丰富的闭塞标本中其数量减少，而在晚期纤维化阶段这些细胞变得不明显。反复的轻微亚临床炎症发作被认为会引发这种病变。
