Laboratory of Physical Activity and Health Promotion, University of Rio de Janeiro State, Rio de Janeiro, Brazil.
Graduate Program in Physical Activity Sciences, Salgado de Oliveira University, Niteroi, Brazil.
Int J Sports Med. 2021 Mar;42(3):246-252. doi: 10.1055/a-1263-1124. Epub 2020 Oct 14.
We investigated the muscle metaboreflex contribution to blood pressure response during dynamic handgrip exercise in men living with HIV (MLHIV) vs. without HIV (Controls). Pressor and heart rate responses were evaluated during metaboreflex activation through post-exercise muscle ischemia (PEMI) method and control exercise session (CER) in 17 MLHIV and 21 Controls. Protocols were performed randomly on the same day, being both sessions composed of 12 min, as follows: a) 3 min at rest, b) 3 min of dynamic handgrip exercise at 30% of maximal voluntary contraction, c) 3 min of recovery post-exercise with vascular occlusion (occlusion only in PEMI), and d) 3 min of recovery post-exercise without vascular occlusion. To assess metaboreflex response, differences between PEMI and CER in recovery post-exercise were calculated for blood pressure and heart rate. Systolic and mean blood pressure (P<0.01) were superior in the last 2 min of recovery with vascular occlusion at PEMI in relation to CER for both groups. No difference was found between groups for blood pressure and heart rate (P>0.05). However, metaboreflex response for systolic blood pressure was lower in MLHIV vs. Controls (4.05±4.63 vs. 7.61±3.99 mmHg; P=0.01). In conclusion, pressor response during metaboreceptor stimulation was attenuated in men living with HIV, which may suggest loss of muscle metaboreflex sensibility.
我们研究了在患有 HIV 的男性（MLHIV）和无 HIV 的男性（对照组）进行动态握力运动期间，肌肉代谢反射对血压反应的贡献。通过运动后肌肉缺血（PEMI）方法和对照运动（CER）评估了压升和心率反应，在 17 名 MLHIV 和 21 名对照组中进行了测试。方案在同一天随机进行，两个阶段均由 12 分钟组成：a）休息 3 分钟，b）最大自主收缩的 30%的动态握力运动 3 分钟，c）运动后恢复 3 分钟，血管阻塞（仅在 PEMI 中阻塞），d）运动后恢复 3 分钟，没有血管阻塞。为了评估代谢反射反应，计算了 PEMI 和 CER 在运动后恢复期间的差异，以评估血压和心率。与 CER 相比，在 PEMI 中，最后 2 分钟的血管阻塞时，收缩压和平均血压（P<0.01）在两组中均较高。两组之间血压和心率无差异（P>0.05）。然而，与对照组相比，MLHIV 的收缩压代谢反射反应较低（4.05±4.63 对 7.61±3.99mmHg；P=0.01）。总之，在患有 HIV 的男性中，代谢感受器刺激时的升压反应减弱，这可能表明肌肉代谢反射敏感性丧失。
