运动训练对 HIV/AIDS 患者肌肉代谢反射自主和血液动力学反应的影响：一项随机临床试验方案。
The effects of exercise training on autonomic and hemodynamic responses to muscle metaboreflex in people living with HIV/AIDS: A randomized clinical trial protocol.
机构信息
Laboratory of Physical Activity and Health Promotion, Institute of Physical Education and Sports, University of Rio de Janeiro State, Rio de Janeiro, RJ, Brazil.
Graduate Program in Exercise and Sports Sciences, University of Rio de Janeiro State, Rio de Janeiro, RJ, Brazil.
出版信息
PLoS One. 2022 Mar 18;17(3):e0265516. doi: 10.1371/journal.pone.0265516. eCollection 2022.
BACKGROUND
People living with HIV (PLHIV) present impaired muscle metaboreflex, which may lead to exercise intolerance and increased cardiovascular risk. The muscle metaboreflex adaptations to exercise training in these patients are unknown. The present study aims to investigate the effects of a supervised multimodal exercise training on hemodynamic and autonomic responses to muscle metaboreflex activation in PLHIV.
METHODS AND DESIGN
In this randomized clinical trial protocol, 42 PLHIV aged 30-50 years will be randomly assigned at a ratio of 1:1 into an intervention or a control group. The intervention group will perform exercise training (3x/week during 12 weeks) and the control group will remain physically inactive. A reference group composed of 21 HIV-uninfected individuals will be included. Primary outcomes will be blood pressure and heart rate variability indices assessed during resting, mental stress, and activation of muscle metaboreflex by a digital sphygmomanometer and a heart rate monitor; respectively. Mental stress will be induced by the Stroop Color-Word test and muscle metaboreflex will be activated through a post-exercise circulatory arrest (PECA) protocol, being the latter performed without and with the application of a capsaicin-based analgesic balm in the exercised limb. Secondary outcomes will be heart rate, peripheral vascular resistance, stroke volume, cardiac output, blood lactate, anthropometric markers and handgrip maximal voluntary contraction. The intervention and control groups of PLHIV will be evaluated at baseline and after the intervention, while the HIV-uninfected reference group only at baseline.
DISCUSSION
The findings of the present study may help to elucidate the muscle metaboreflex adaptations to exercise training in PLHIV.
TRIAL REGISTRATION
This study will be performed at University of Rio de Janeiro State following registration at ClinicalTrials.gov as NCT04512456 on August 13, 2020.
背景
感染人类免疫缺陷病毒（HIV）的患者（PLHIV）存在肌肉代谢反射受损的情况，这可能导致运动不耐受和心血管风险增加。目前尚不清楚这些患者的肌肉代谢反射对运动训练的适应情况。本研究旨在探讨监督下的多模式运动训练对 PLHIV 肌肉代谢反射激活时的血液动力学和自主神经反应的影响。
方法和设计
在本随机临床试验方案中，将 42 名年龄在 30-50 岁之间的 PLHIV 按照 1:1 的比例随机分配到干预组或对照组。干预组将进行运动训练（每周 3 次，持续 12 周），对照组则保持身体不活动。将纳入一个由 21 名 HIV 未感染者组成的参考组。主要结局将是使用数字血压计和心率监测器在休息、心理应激和肌肉代谢反射激活时评估血压和心率变异性指数；分别。心理应激将通过 Stroop 颜色-单词测试来诱导，肌肉代谢反射将通过运动后循环停止（PECA）方案来激活，后者在不使用和使用辣椒素类镇痛膏在运动肢体的情况下进行。次要结局将是心率、外周血管阻力、每搏输出量、心输出量、血乳酸、人体测量标记物和握力最大自愿收缩。PLHIV 的干预组和对照组将在基线和干预后进行评估，而 HIV 未感染的参考组仅在基线时进行评估。
讨论
本研究的结果可能有助于阐明 PLHIV 对运动训练的肌肉代谢反射适应情况。
试验注册
该研究将在里约热内卢州立大学进行，并于 2020 年 8 月 13 日在 ClinicalTrials.gov 上注册为 NCT04512456。
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