Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Immunol Invest. 2022 Jan;51(1):154-169. doi: 10.1080/08820139.2020.1817067. Epub 2020 Oct 15.
One of the leading causes of death in the intensive care unit (ICU) is sepsis. Different studies have been performed on different markers to determine the cause of sepsis. microRNAs (miRNAs) are non-coding RNAs that can be released both inside and outside the cell and regulate the target gene expression by binding to the 3' untranslated region (3'UTR) of the target genes. TLRs play an important role in innate immunity that can be modulated by biological markers such as microRNAs. In this study, we summarized the recent progress on the role of extracellular and intracellular microRNAs in sepsis. It has also been focused on the association of TLRs with extracellular and intracellular micro RNAs in the regulation of sepsis. In conclusion, this study has provided new insight into the role of microRNAs as a regulator of the TLRs which may lead to the aberrant inflammatory response in sepsis. Therefore, it suggests that both intracellular and extracellular microRNAs may play a therapeutic role in the treatment of sepsis via regulating TLRs. However, yet sepsis and septic shock are medical emergencies and further studies are needed to specify the exact role of microRNAs and TLRs in sepsis.
在重症监护病房（ICU）中，死亡的主要原因之一是败血症。不同的研究已经针对不同的标志物进行了研究，以确定败血症的原因。微小 RNA（miRNA）是一种非编码 RNA，可以在细胞内外释放，并通过与靶基因的 3'非翻译区（3'UTR）结合来调节靶基因的表达。TLR 在先天免疫中发挥重要作用，可以通过生物标志物如微小 RNA 进行调节。在这项研究中，我们总结了细胞外和细胞内微小 RNA 在败血症中的作用的最新进展。它还集中于 TLR 与细胞外和细胞内微小 RNA 在调节败血症中的关联。总之，这项研究为微小 RNA 作为 TLR 调节剂的作用提供了新的见解，这可能导致败血症中异常的炎症反应。因此，它表明细胞内和细胞外微小 RNA 可能通过调节 TLR 在治疗败血症中发挥治疗作用。然而，败血症和感染性休克仍然是医疗紧急情况，需要进一步的研究来确定微小 RNA 和 TLR 在败血症中的确切作用。
