Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton.
Department of Paediatric Immunology and Infectious Diseases, Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Curr Opin Infect Dis. 2020 Dec;33(6):530-539. doi: 10.1097/QCO.0000000000000688.
Studies indicating that non-coding RNAs (ncRNAs) play a regulatory role in sepsis are increasing rapidly. This present review summarizes recent publications on the role of microRNAs and long non-coding RNAs (lncRNAs) in sepsis.
MicroRNAs (miRNAs) and lncRNAs are being identified as potential sepsis biomarkers and therapeutic targets. Experimental studies have examined the biological mechanisms that might underpin the regulatory role of these ncRNAs in sepsis.
Clinical applications of miRNAs and lncRNAs in sepsis are on the horizon. These data could lead to the identification of novel treatments or indeed support the repurposing of existing drugs for sepsis. Validation of the findings from these preliminary studies and crucially integration of multiomics datasets will undoubtedly revolutionize the clinical management of sepsis.
越来越多的研究表明非编码 RNA（ncRNA）在脓毒症中发挥着调控作用。本综述总结了 microRNAs 和长非编码 RNA（lncRNA）在脓毒症中的作用的最新研究进展。
microRNAs（miRNAs）和 lncRNAs 被认为是脓毒症潜在的生物标志物和治疗靶点。实验研究已经研究了这些 ncRNA 在脓毒症中发挥调控作用的潜在生物学机制。
miRNAs 和 lncRNAs 在脓毒症中的临床应用即将出现。这些数据可能会为脓毒症的新型治疗方法提供依据，甚至可以支持重新利用现有药物治疗脓毒症。对这些初步研究结果的验证，以及多组学数据集的整合，无疑将彻底改变脓毒症的临床管理。
