Zhu Jianlong, Song Changjun, Cai Tingting, Yi Lulu, Zhang Wei, Zhong Jing, Shen Meirong
Department of Critical Care Medicine, Ganzhou People's Hospital, Ganzhou 341000, China.
Department of Emergency, Ganzhou People's Hospital, Ganzhou 341000, China.
Cardiol Res Pract. 2022 Aug 27;2022:8570486. doi: 10.1155/2022/8570486. eCollection 2022.
The objective is to investigate the relationship between sepsis complicated with heart failure and the expression levels of CXC chemokine ligand 8 (CXCL8) and endothelin-1 (ET-1).
A total of 128 sepsis patients accepted by the Ganzhou People's Hospital from March 2019 to December 2021 were collected as observation objects, and they were separated into a simple sepsis group (86 cases) and a complicated heart failure group (42 cases) according to whether they were accompanied by heart failure or not. General data such as Sequential Organ Failure Assessment (SOFA) score and Acute Physiology and Chronic Health Evaluation II (APACHE II) were collected; the expression levels of serum CXCL8 and ET-1 were detected by enzyme-linked immunosorbent assay (ELISA); the cardiac function parameters such as left ventricular ejection fraction (LVEF), stroke volume (SV), cardiac output (CO), and cardiac index (CI) were measured by color Doppler ultrasound; the correlation between serum CXCL8 and ET-1 expression levels with clinical data and cardiac function parameters in patients with sepsis complicated with heart failure was analyzed by the Pearson correlation; and the influencing factors of sepsis complicated with heart failure were analyzed by the logistic regression analysis.
The serum CXCL8 and ET-1 expression levels, SOFA score, and APACHE II score in the complicated heart failure group were higher than those in the simple sepsis group ( < 0.05), and LVEF, SV, CO, and CI in the complicated heart failure group were lower than those in the simple sepsis group ( < 0.05). Serum CXCL8 was positively correlated with ET-1 in patients with sepsis complicated with heart failure ( = 0.531, < 0.05), and the two were positively correlated with SOFA score and APACHE II score ( < 0.05) and were negatively correlated with LVEF, SV, CO, and CI ( < 0.05). CXCL8 and ET-1 were independent risk factors for sepsis complicated with heart failure ( < 0.05).
The expression levels of serum CXCL8 and ET-1 in sepsis patients with heart failure are significantly increased, and both are risk factors for heart failure in sepsis patients.
探讨脓毒症合并心力衰竭与CXC趋化因子配体8（CXCL8）及内皮素-1（ET-1）表达水平的关系。
收集2019年3月至2021年12月赣州市人民医院收治的128例脓毒症患者作为观察对象，根据是否合并心力衰竭分为单纯脓毒症组（86例）和合并心力衰竭组（42例）。收集序贯器官衰竭评估（SOFA）评分、急性生理与慢性健康状况评分系统II（APACHE II）等一般资料；采用酶联免疫吸附测定（ELISA）法检测血清CXCL8和ET-1表达水平；用彩色多普勒超声测量左心室射血分数（LVEF）、每搏输出量（SV）、心输出量（CO）、心脏指数（CI）等心功能参数；采用Pearson相关性分析脓毒症合并心力衰竭患者血清CXCL8和ET-1表达水平与临床资料及心功能参数的相关性；采用Logistic回归分析脓毒症合并心力衰竭的影响因素。
合并心力衰竭组血清CXCL8和ET-1表达水平、SOFA评分及APACHE II评分均高于单纯脓毒症组（P<0.05），合并心力衰竭组LVEF、SV、CO及CI均低于单纯脓毒症组（P<0.05）。脓毒症合并心力衰竭患者血清CXCL8与ET-1呈正相关（r=0.531，P<0.05），二者与SOFA评分和APACHE II评分呈正相关（P<0.05），与LVEF、SV、CO及CI呈负相关（P<0.05）。CXCL8和ET-1是脓毒症合并心力衰竭的独立危险因素（P<0.05）。
心力衰竭脓毒症患者血清CXCL8和ET-1表达水平显著升高，二者均为脓毒症患者发生心力衰竭的危险因素。
