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Epstein-Barr virus-specific T cell therapy for progressive multiple sclerosis.

作者信息

Pender Michael P, Csurhes Peter A, Smith Corey, Douglas Nanette L, Neller Michelle A, Matthews Katherine K, Beagley Leone, Rehan Sweera, Crooks Pauline, Hopkins Tracey J, Blum Stefan, Green Kerryn A, Ioannides Zara A, Swayne Andrew, Aftab Blake T, Hooper Kaye D, Burrows Scott R, Thompson Kate M, Coulthard Alan, Khanna Rajiv

出版信息

JCI Insight. 2020 Oct 15;5(20):144624. doi: 10.1172/jci.insight.144624.

DOI:10.1172/jci.insight.144624
PMID:33055421
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7605530/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e96/7605530/6840a48304a7/jciinsight-5-144624-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e96/7605530/6840a48304a7/jciinsight-5-144624-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e96/7605530/6840a48304a7/jciinsight-5-144624-g001.jpg

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Epstein-Barr virus-specific T cell therapy for progressive multiple sclerosis.用于进行性多发性硬化症的爱泼斯坦-巴尔病毒特异性T细胞疗法。
JCI Insight. 2020 Oct 15;5(20):144624. doi: 10.1172/jci.insight.144624.
2
Cerebrospinal fluid CD4+ T cells from a multiple sclerosis patient cross-recognize Epstein-Barr virus and myelin basic protein.来自一名多发性硬化症患者的脑脊液CD4 + T细胞可交叉识别爱泼斯坦-巴尔病毒和髓鞘碱性蛋白。
J Neurovirol. 2004 Oct;10(5):278-83. doi: 10.1080/13550280490499524.
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Cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus-transformed B cells.来自多发性硬化症患者的脑脊液T细胞识别自体爱泼斯坦-巴尔病毒转化的B细胞。
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Targeting Epstein-Barr virus infection as an intervention against multiple sclerosis.将靶向爱泼斯坦-巴尔病毒感染作为治疗多发性硬化症的一种干预措施。
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The association between multiple sclerosis and infection with Epstein-Barr virus and retrovirus.多发性硬化症与爱泼斯坦-巴尔病毒及逆转录病毒感染之间的关联。
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Epstein-Barr Virus-Specific CD8 T Cells Selectively Infiltrate the Brain in Multiple Sclerosis and Interact Locally with Virus-Infected Cells: Clue for a Virus-Driven Immunopathological Mechanism.EBV 特异性 CD8 T 细胞在多发性硬化症中选择性浸润大脑并与病毒感染细胞局部相互作用:病毒驱动免疫病理机制的线索。
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[Infection by Epstein-Barr virus and multiple sclerosis].[爱泼斯坦-巴尔病毒感染与多发性硬化症]
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Absence of Epstein-Barr virus RNA in multiple sclerosis as assessed by in situ hybridisation.通过原位杂交评估多发性硬化症中爱泼斯坦-巴尔病毒RNA的缺失情况。
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Multiple sclerosis: the elevated antibody response to Epstein-Barr virus primarily targets, but is not confined to, the glycine-alanine repeat of Epstein-Barr nuclear antigen-1.多发性硬化症:针对 Epstein-Barr 病毒的高抗体反应主要针对,但不仅限于,Epstein-Barr 核抗原-1 的甘氨酸-丙氨酸重复序列。
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Response to 'Seasonal variation of vitamin D and Epstein-Barr virus antibody in multiple sclerosis patients', a comment letter regarding 'Vitamin D, HLA-DRB1 and Epstein-Barr virus antibody levels in a prospective cohort of multiple sclerosis patients'.对“多发性硬化症患者中维生素D和爱泼斯坦-巴尔病毒抗体的季节性变化”的回应,这是一封关于“前瞻性多发性硬化症患者队列中维生素D、HLA-DRB1和爱泼斯坦-巴尔病毒抗体水平”的评论信。
Eur J Neurol. 2018 Sep;25(9):e104. doi: 10.1111/ene.13719.

引用本文的文献

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Ineffective control of Epstein-Barr virus infection is seen in MS: What is next?在多发性硬化症中可见爱泼斯坦-巴尔病毒感染控制无效:接下来会怎样?
Clin Transl Med. 2024 Feb;14(2):e1596. doi: 10.1002/ctm2.1596.
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FKBP5 activates mitophagy by ablating PPAR-γ to shape a benign remyelination environment.FKBP5 通过消除 PPAR-γ 来激活细胞自噬,从而塑造良性的髓鞘修复环境。
Cell Death Dis. 2023 Nov 11;14(11):736. doi: 10.1038/s41419-023-06260-7.
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Treatment Options for Epstein-Barr Virus-Related Disorders of the Central Nervous System.爱泼斯坦-巴尔病毒相关中枢神经系统疾病的治疗选择
Infect Drug Resist. 2023 Jul 13;16:4599-4620. doi: 10.2147/IDR.S375624. eCollection 2023.
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Roadmap for understanding mechanisms on how Epstein-Barr virus triggers multiple sclerosis and for translating these discoveries in clinical trials.了解爱泼斯坦-巴尔病毒引发多发性硬化症机制以及将这些发现转化到临床试验中的路线图。
Clin Transl Immunology. 2023 Feb 16;12(2):e1438. doi: 10.1002/cti2.1438. eCollection 2023.
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Epstein-Barr virus as a leading cause of multiple sclerosis: mechanisms and implications.EB 病毒是多发性硬化症的主要病因:机制和意义。
Nat Rev Neurol. 2023 Mar;19(3):160-171. doi: 10.1038/s41582-023-00775-5. Epub 2023 Feb 9.
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The role of the complement system in Multiple Sclerosis: A review.补体系统在多发性硬化症中的作用:综述。
Front Immunol. 2022 Aug 10;13:970486. doi: 10.3389/fimmu.2022.970486. eCollection 2022.
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Novel Drugs in a Pipeline for Progressive Multiple Sclerosis.用于进展型多发性硬化症的在研新药
J Clin Med. 2022 Jun 10;11(12):3342. doi: 10.3390/jcm11123342.
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SARS-CoV-2-specific T cells generated for adoptive immunotherapy are capable of recognizing multiple SARS-CoV-2 variants.用于过继免疫疗法的 SARS-CoV-2 特异性 T 细胞能够识别多种 SARS-CoV-2 变体。
PLoS Pathog. 2022 Feb 14;18(2):e1010339. doi: 10.1371/journal.ppat.1010339. eCollection 2022 Feb.
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Current and emerging disease-modulatory therapies and treatment targets for multiple sclerosis.多发性硬化症的现有和新兴疾病调节疗法及治疗靶点。
J Intern Med. 2021 Jun;289(6):771-791. doi: 10.1111/joim.13215. Epub 2020 Dec 20.